肿瘤细胞与内皮细胞的交叉路口。
The crossroad between tumor and endothelial cells.
机构信息
Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Università Degli Studi Di Bari, Piazza Giulio Cesare 11, 70125, Bari, Italy.
出版信息
Clin Exp Med. 2024 Sep 26;24(1):227. doi: 10.1007/s10238-024-01490-1.
Endothelial cells are critical in tumor development, and the specific targeting of endothelial cells offers a potent means to effectively impede angiogenesis and suppress the growth of tumors. Tumor endothelial cells are responsible for the loss of anticancer immunity, the so-called endothelial anergy, i.e., the unresponsiveness of tumor endothelial cells to pro-inflammatory stimulation, not allowing adhesion of immune cells to the endothelium. Endothelial cells downregulate antigen presentation and recruitment of immune cells, contributing to immunosuppression. Targeting endothelial cells may assist in improving the immune effect of immune cells in tumor microenvironment.
内皮细胞在肿瘤发展中起着至关重要的作用，而内皮细胞的特异性靶向治疗为有效抑制血管生成和肿瘤生长提供了有力手段。肿瘤内皮细胞导致抗肿瘤免疫的丧失，即所谓的内皮失能，即肿瘤内皮细胞对促炎刺激无反应，不允许免疫细胞黏附在内皮上。内皮细胞下调抗原呈递和免疫细胞募集，导致免疫抑制。靶向内皮细胞可能有助于改善肿瘤微环境中免疫细胞的免疫效果。
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