Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China.
The First Affiliated Hospital of China Medical University, General Medicine, Shenyang, Liaoning, China.
J Glob Health. 2024 Sep 27;14:04154. doi: 10.7189/jogh.14.04154.
The interinfluence of thyroid function and daily physical activity (PA) remains unclear. We examined the causal relationship between genetically proxied thyroid-related traits; hypothyroidism, hyperthyroidism, thyroid stimulating hormone (TSH) and free thyroxine (FT4), and daily PA measures; leisure screen time (LST) and moderate-to-vigorous physical activity (MVPA), using Mendelian randomisation (MR) analysis.
We used genome-wide association study (GWAS) data from the ThyroidOmics Consortium and the most comprehensive meta-analysis on PA, comprising data on hypothyroidism (n = 53 423), hyperthyroidism (n = 51 823), TSH within the reference range (n = 54 288), fT4 within the reference range (n = 49 269), LST (n = 526 725), and MVPA (n = 608 595) to conduct a bidirectional two-sample MR analysis. The inverse variance weighted (IVW) method was employed as the primary result. Sensitivity analyses included MR-Egger, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) regression. Similar investigations were conducted in the reverse direction. Finally, we analysed a multivariable MR using body mass index (BMI)-related traits GWAS data.
In the primary IVW analysis, an increase in genetically proxied TSH levels significantly increased LST (correlation coefficient (β) = 0.040; 95% confidence interval (CI) = 0.020-0.061, P = 9.776 × 10). The multivariable MR analysis indicated that the positive causal effect still existed when considering the influence of BMI (MVMR-IVW: β = 0.042; 95% CI = 0.011-0.073, P = 0.007). Conversely, there was no evidence to suggest that PA impacts thyroid function.
The results of this MR analysis suggest that thyroid function influences daily PA. The positive association between TSH and LST is not confounded or mediated by BMI.
甲状腺功能与日常体力活动（PA）之间的相互影响尚不清楚。我们使用孟德尔随机化（MR）分析来检查甲状腺相关特征（甲状腺功能减退症、甲状腺功能亢进症、促甲状腺激素（TSH）和游离甲状腺素（FT4））与日常 PA 测量值（休闲屏幕时间（LST）和中高强度体力活动（MVPA）之间的因果关系。
我们使用甲状腺组学联盟的全基因组关联研究（GWAS）数据和关于 PA 的最全面的荟萃分析，包括甲状腺功能减退症（n=53423）、甲状腺功能亢进症（n=51823）、参考范围内的 TSH（n=54288）、参考范围内的 fT4（n=49269）、LST（n=526725）和 MVPA（n=608595）的数据进行双向两样本 MR 分析。反向方差加权（IVW）法作为主要结果。敏感性分析包括 MR-Egger、加权中位数和 MR 多效残余总和和异常值（MR-PRESSO）回归。在反向方向进行了类似的研究。最后，我们使用与体重指数（BMI）相关特征的 GWAS 数据进行了多变量 MR 分析。
在主要的 IVW 分析中，遗传上接近的 TSH 水平升高显著增加了 LST（相关系数（β）=0.040；95%置信区间（CI）=0.020-0.061，P=9.776×10-8）。多变量 MR 分析表明，当考虑 BMI 的影响时，正向因果关系仍然存在（MVMR-IVW：β=0.042；95%CI=0.011-0.073，P=0.007）。相反，没有证据表明 PA 会影响甲状腺功能。
这项 MR 分析的结果表明，甲状腺功能会影响日常 PA。TSH 与 LST 之间的正相关关系不受 BMI 的影响或介导。
