Hu Yu-Xin, Hu Can, Hu Min, Gao Yi-Peng, Dong Wen-Sheng, Li Kang, Ye Yun-Jia, Zhang Xin
Department of Geriatrics, Renmin Hospital of Wuhan University, Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan 430060, China.
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
Aging Dis. 2024 May 4;16(3):1471-1482. doi: 10.14336/AD.2024.0381.
Fibronectin (FN) can bind to certain integrin receptors on the cell surface through short peptide sequences, thereby transmitting extracellular stimuli to intracellular effector molecules. FNDC4 plays a similar role due to the constitution of a type III FN domain, which is a binding site for DNA, heparin, or cell surface. It mainly functions as a signal transmitter after being cleaved and secreted as the extracellular N-terminal fibronectin type III domain (sFNDC4). Emerging studies have shown that FNDC4 plays crucial roles in numerous diseases and holds significant implications for guiding clinical treatment. This review aims to summarize the different roles and the latest advances of FNDC4 in the development of various diseases, in order to provide new ideas for clinical treatment.
纤连蛋白（FN）可通过短肽序列与细胞表面的某些整合素受体结合，从而将细胞外刺激传递至细胞内效应分子。由于Ⅲ型FN结构域的构成，FNDC4发挥类似作用，该结构域是DNA、肝素或细胞表面的结合位点。它主要在被切割并作为细胞外N端纤连蛋白Ⅲ型结构域（sFNDC4）分泌后作为信号转导分子发挥作用。新兴研究表明，FNDC4在众多疾病中起关键作用，对指导临床治疗具有重要意义。本综述旨在总结FNDC4在各种疾病发生发展中的不同作用及最新进展，为临床治疗提供新思路。
