Feng Haiwen, Li Junjin, Wang Hongda, Wei Zhijian, Feng Shiqing
Tianjin Key Laboratory of Spine and Spinal Cord, International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, International Chinese Musculoskeletal Research Society Collaborating Center for Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin 300070, China.
Orthopedic Research Center of Shandong University and Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Aging Dis. 2024 Aug 26;16(4):2177-2200. doi: 10.14336/AD.2024.0755.
Senescence is a cellular state characterized by an irreversible halt in the cell cycle, accompanied by alterations in cell morphology, function, and secretion. Senescent cells release a plethora of inflammatory and growth factors, extracellular matrix proteins, and other bioactive substances, collectively known as the senescence-associated secretory phenotype (SASP). These excreted substances serve as crucial mediators of senescent tissues, while the secretion of SASP by senescent neurons and glial cells in the central nervous system modulates the activity of immune cells. Senescent immune cells also influence the physiological activities of various cells in the central nervous system. Further, the interaction between cellular senescence and immune regulation collectively affects the physiological and pathological processes of the central nervous system. Herein, we explore the role of senescence in the physiological and pathological processes underlying embryonic development, aging, degeneration, and injury of the central nervous system, through the immune response. Further, we elucidate the role of senescence in the physiological and pathological processes of the central nervous system, proposing a new theoretical foundation for treating central nervous system diseases.
衰老（过程）是一种细胞状态，其特征为细胞周期的不可逆停滞，并伴有细胞形态、功能及分泌的改变。衰老细胞会释放大量炎性因子、生长因子、细胞外基质蛋白及其他生物活性物质，这些物质统称为衰老相关分泌表型（SASP）。这些分泌物质是衰老组织的关键介质，而中枢神经系统中衰老神经元和胶质细胞分泌的SASP会调节免疫细胞的活性。衰老的免疫细胞也会影响中枢神经系统中各种细胞的生理活动。此外，细胞衰老与免疫调节之间的相互作用共同影响着中枢神经系统的生理和病理过程。在此，我们通过免疫反应探讨衰老在中枢神经系统胚胎发育、衰老、退变及损伤等生理和病理过程中的作用。此外，我们阐明衰老在中枢神经系统生理和病理过程中的作用，为治疗中枢神经系统疾病提出新的理论基础。
