Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Northwestern Feinberg School of Medicine, Chicago, Illinois.
Obstet Gynecol. 2024 Dec 1;144(6):e121-e124. doi: 10.1097/AOG.0000000000005749. Epub 2024 Sep 26.
To evaluate oocyte cryopreservation among transgender and gender-diverse adolescents and young adults with or without prior testosterone exposure, we performed a retrospective cohort study of all patients younger than age 35 years referred for oocyte cryopreservation through our formal fertility-preservation program from 2014 to 2023. The number of patients referred and pursuing fertility preservation increased over time. Among the 93 patients referred, 37 pursued oocyte cryopreservation (31 testosterone-naïve and six testosterone-exposed). Among the latter, neither length of time on testosterone before presentation nor duration off testosterone before retrieval (minimum 2 months) were associated with the number of mature oocytes frozen. When comparing testosterone-naïve with testosterone-exposed individuals, there was no difference in number of oocytes retrieved (median 28 vs 32, P =0.43) or mature oocytes frozen (21 vs 21, P =0.95).
为了评估有或没有先前接受睾酮治疗的跨性别和性别多样化的青少年和年轻成年人的卵母细胞冷冻保存情况，我们对所有年龄小于 35 岁的患者进行了回顾性队列研究，这些患者通过我们的正式生育保护计划于 2014 年至 2023 年期间被转介进行卵母细胞冷冻保存。被转介和寻求生育保护的患者人数随着时间的推移而增加。在 93 名被转介的患者中，有 37 名接受了卵母细胞冷冻保存（31 名未接受过睾酮治疗，6 名接受过）。在后者中，就诊前接受睾酮治疗的时间长短或取卵前停药的时间（至少 2 个月）均与冷冻成熟卵母细胞的数量无关。在比较未接受过睾酮治疗和接受过睾酮治疗的个体时，取卵数量（中位数分别为 28 个与 32 个，P =0.43）或冷冻成熟卵母细胞的数量（分别为 21 个与 21 个，P =0.95）均无差异。
