Department of Translational Biomedicine and Neuroscience - DiBraiN, University of Bari "Aldo Moro", 70124 Bari, Italy.
Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Discov Med. 2024 Sep;36(188):1772-1779. doi: 10.24976/Discov.Med.202436188.163.
Aging is frequently associated with a progressive increase in chronic low-grade inflammation, known as "inflammaging". Numerous studies have shown that inflammaging is closely linked to the development of several age-related diseases. However, the underlying mechanism and its causal role are still not fully understood despite this association. In the complex context of aging, mesenchymal stem cells (MSCs) undergo changes in behavior and functionality. This narrative topical review examines the recent advances in aging research, specifically focusing on the role of inflammaging and related mechanisms that contribute to age-related chronic diseases. The authors critically investigated whether and how inflammaging, epigenetic damage, mitochondrial changes, and macrophage alterations may influence stem cell behavior, highlighting the interplay between these factors and their potential therapeutic implications. By elucidating the mechanisms underlying these processes, we can gain valuable insights into the maintenance and regeneration of stem cell populations, providing the basis for novel therapeutic strategies targeting age-related decline and disease progression.
衰老通常与慢性低度炎症的逐渐增加有关，这种炎症被称为“炎症衰老”。许多研究表明，炎症衰老与几种与年龄相关的疾病的发展密切相关。然而，尽管存在这种关联，但炎症衰老的潜在机制及其因果作用仍未完全理解。在衰老的复杂背景下，间充质干细胞（MSCs）的行为和功能发生变化。本综述性专题评论探讨了衰老研究的最新进展，特别关注炎症衰老和相关机制在与年龄相关的慢性疾病中的作用。作者批判性地研究了炎症衰老、表观遗传损伤、线粒体变化和巨噬细胞改变是否以及如何影响干细胞行为，强调了这些因素之间的相互作用及其潜在的治疗意义。通过阐明这些过程的机制，我们可以深入了解干细胞群体的维持和再生，为针对与年龄相关的衰退和疾病进展的新型治疗策略提供基础。
