Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India.
Neurosurg Rev. 2024 Sep 27;47(1):697. doi: 10.1007/s10143-024-02924-w.
This study by Zuo et al. (2024) investigates the prognostic significance of C-reactive protein (CRP) levels, the prognostic nutritional index (PNI), and the lactate dehydrogenase-to-lymphocyte ratio (LLR) in primary central nervous system lymphoma (PCNSL) using data from 223 patients. The research demonstrates that these markers are critical in predicting patient outcomes, offering novel insights beyond traditional prognostic models like the MSKCC and IELSG scores. Despite its strengths, the study's retrospective design and lack of validation cohort limit its generalizability. Future research should focus on validating these findings in diverse, multicenter settings and integrating these markers with existing prognostic models to improve clinical decision-making. Longitudinal studies and advanced statistical methods are recommended to further explore the interactions between these factors and their impact on patient outcomes, potentially leading to the development of targeted therapies for PCNSL.
这项由左等人（2024 年）进行的研究利用 223 名患者的数据，探讨了 C 反应蛋白（CRP）水平、预后营养指数（PNI）和乳酸脱氢酶与淋巴细胞比值（LLR）在原发性中枢神经系统淋巴瘤（PCNSL）中的预后意义。研究表明，这些标志物对于预测患者预后至关重要，提供了超越 MSKCC 和 IELSG 评分等传统预后模型的新见解。尽管该研究具有优势，但由于其回顾性设计和缺乏验证队列，限制了其推广性。未来的研究应侧重于在不同的多中心环境中验证这些发现，并将这些标志物与现有的预后模型相结合，以改善临床决策。建议进行纵向研究和采用先进的统计方法，以进一步探讨这些因素之间的相互作用及其对患者预后的影响，从而可能为 PCNSL 开发靶向治疗方法。
