Sharath S, Kadavigere Rajagopal, Maiya G Arun
Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Department of Radio Diagnosis and Imaging, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Curr Diabetes Rev. 2025;21(10):50-58. doi: 10.2174/0115733998310010240711051523.
Diabetic peripheral neuropathy (DPN) is the prevalent microvascular complication of diabetes mellitus (DM). 30-50% of diabetics are likely to be affected by DPN. It significantly impacts the skeletal muscles, resulting in an accelerated loss of muscle mass. The objective of this systematic review was to evaluate the ankle and foot muscle changes in diabetic peripheral neuropathy using ultrasound.
A comprehensive search was conducted in Scopus, Embase, and PubMed databases, which yielded 64 studies, out of which 5 studies are included in this meta-analysis.
The meta-analysis shows that the thickness and cross-section area of the extensor digitorum brevis muscle are reduced in DPN as compared to the control group with p-value<0.004 and p-value<0.001, respectively. The thickness of MIL muscle was also smaller in DPN p-value=0.02. Similarly, the thickness and CSA of AH muscle are also reduced in DPN patients compared to the control group, with p-values of 0.21 and 0.14.
Meta-analysis reveals that diabetic peripheral neuropathy (DPN) patients have reduced foot muscle thickness and cross-sectional area (CSA) compared to controls without neuropathy. This highlights the importance of ultrasound in detecting muscle atrophy early in diabetic patients since it provides objective measures beyond traditional screening with its real-time and non-invasive nature.
糖尿病周围神经病变（DPN）是糖尿病（DM）常见的微血管并发症。30%-50%的糖尿病患者可能受到DPN影响。它对骨骼肌有显著影响，导致肌肉质量加速流失。本系统评价的目的是使用超声评估糖尿病周围神经病变患者踝关节和足部肌肉的变化。
在Scopus、Embase和PubMed数据库中进行全面检索，共获得64项研究，其中5项研究纳入本荟萃分析。
荟萃分析表明，与对照组相比，DPN患者的趾短伸肌厚度和横截面积减小，p值分别<0.004和<0.001。DPN患者的内侧蚓状肌厚度也较小，p值=0.02。同样，与对照组相比，DPN患者的拇收肌厚度和横截面积也减小，p值分别为0.21和0.14。
荟萃分析显示，与无神经病变的对照组相比，糖尿病周围神经病变（DPN）患者足部肌肉厚度和横截面积（CSA）减小。这突出了超声在早期检测糖尿病患者肌肉萎缩方面的重要性，因为它凭借实时、非侵入性的特点提供了超越传统筛查的客观测量方法。
