Gill Karambir Singh, Gupta Bhavna, Pooni Puneet A, Bhargava Siddharth
Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, India.
Front Pediatr. 2024 Sep 12;12:1441553. doi: 10.3389/fped.2024.1441553. eCollection 2024.
This study was undertaken to find the clinical correlation of resistive index (RI) in the anterior cerebral artery (ACA) of preterm neonates admitted to the Neonatal Intensive care unit (NICU) with comorbidities such as perinatal asphyxia, neonatal sepsis, and necrotizing enterocolitis (NEC).
An observational analytical study was conducted, including preterm neonates (<35 weeks) admitted to the NICU. Ultrasound cranium scans were performed on days 1-3 and 7 of life as per the study protocol. Baseline and clinical data of asphyxia, sepsis, and NEC were obtained. Images were acquired using a 4-8-MHz probe on a Sonosite M-turbo machine (Bothell, WA, USA). All statistical calculations were done using SPSS version 21.0 (SPSS Inc., Chicago, IL, USA) with the application of the Kolmogorov-Smirnov test and the Mann-Whitney test.
During the study period, a total of 739 neonates were admitted. Of these, 73 neonates constituted the study group. Among the 73 patients, 33 were preterm neonates without comorbidities and 40 neonates had comorbidities such as perinatal asphyxia, sepsis, and NEC stage 2 and 3 (necrotizing enterocolitis). In the present study, the mean RI on day 3 of life was 0.76 ± 0.04 in neonates without comorbidities and 0.77 ± 0.04 in neonates with comorbidities, with a -value of 0.247. On the 7th day of life, the mean RI was 0.82 ± 0.03 in both groups, with a -value of 0.42.
We could not find any significant clinical correlation of RI in the ACA of preterm neonates <35 weeks of gestation with comorbidities.
本研究旨在探寻入住新生儿重症监护病房（NICU）的早产儿大脑前动脉（ACA）阻力指数（RI）与围产期窒息、新生儿败血症和坏死性小肠结肠炎（NEC）等合并症之间的临床相关性。
开展了一项观察性分析研究，纳入入住NICU的早产儿（<35周）。根据研究方案，在出生后第1 - 3天和第7天进行头颅超声扫描。获取窒息、败血症和NEC的基线及临床数据。使用美国华盛顿州博塞尔市索诺声M - turbo超声诊断仪，配备4 - 8MHz探头采集图像。所有统计计算均使用SPSS 21.0版软件（美国伊利诺伊州芝加哥市SPSS公司），应用柯尔莫哥洛夫 - 斯米尔诺夫检验和曼 - 惠特尼检验。
研究期间，共收治739例新生儿。其中，73例新生儿构成研究组。在这73例患者中，33例为无合并症的早产儿，40例新生儿患有围产期窒息、败血症以及NEC 2期和3期（坏死性小肠结肠炎）等合并症。在本研究中，无合并症新生儿出生后第3天的平均RI为0.76±0.04，有合并症新生儿为0.77±0.04，P值为0.247。出生后第7天，两组的平均RI均为0.82±0.03，P值为0.42。
我们未发现孕周<35周且患有合并症的早产儿ACA中RI存在任何显著的临床相关性。
