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晚期早产儿呼吸道疾病的种族差异:一项回顾性队列研究。

Racial Differences in Respiratory Morbidity in Late Preterm Infants: A Retrospective Cohort Study.

作者信息

Dassios Theodore, Jenkinson Allan, Bhat Ravindra, Greenough Anne

机构信息

King's College London, London, UK.

University of Patras, Patras, Greece.

出版信息

Glob Pediatr Health. 2024 Sep 18;11:2333794X241273151. doi: 10.1177/2333794X241273151. eCollection 2024.

DOI:10.1177/2333794X241273151
PMID:39329161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11425724/
Abstract

. The role of race in late preterm respiratory morbidity has not been adequately described. We aimed to determine whether neonatal respiratory morbidity differs between Black and White late preterm infants. . Single-centre retrospective cohort study at King's College Hospital NHS Foundation Trust, London, UK of infants born at 34 to <37 weeks of gestational age. The incidence of invasive ventilation was used as the main outcome. . In the study period 354 Black and 673 White late preterm infants were admitted. Black, compared to white infants, had a lower incidence of invasive ventilation (19% vs 27%,  < .001) and a lower incidence of non-invasive ventilation (22% vs 34%,  < .001). Black infants had a shorter duration and cost of stay compared to White infants ( = .011 and <0.001 respectively). . Black late preterm infants needed less frequently invasive and non-invasive ventilation and had a shorter duration and cost of stay compared to White late preterm infants.

摘要

种族在晚期早产儿呼吸疾病中的作用尚未得到充分描述。我们旨在确定黑人与白人晚期早产儿的新生儿呼吸疾病是否存在差异。

在英国伦敦国王学院医院国民保健服务信托基金进行的单中心回顾性队列研究,研究对象为孕周34至<37周出生的婴儿。有创通气的发生率被用作主要结局指标。

在研究期间,共收治了354名黑人晚期早产儿和673名白人晚期早产儿。与白人婴儿相比,黑人婴儿有创通气的发生率较低(19%对27%,<0.001),无创通气的发生率也较低(22%对34%,<0.001)。与白人婴儿相比,黑人婴儿的住院时间更短,住院费用更低(分别为P = 0.011和P<0.001)。

与白人晚期早产儿相比,黑人晚期早产儿需要有创和无创通气的频率更低,住院时间更短,住院费用更低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b5/11425724/8a630d4c278b/10.1177_2333794X241273151-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b5/11425724/8a630d4c278b/10.1177_2333794X241273151-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b5/11425724/8a630d4c278b/10.1177_2333794X241273151-fig1.jpg

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本文引用的文献

1
Race, hypoxaemia and oxidative stress in prematurely-born infants.早产儿的种族、低氧血症和氧化应激。
Early Hum Dev. 2023 Jul;182:105778. doi: 10.1016/j.earlhumdev.2023.105778. Epub 2023 Apr 27.
2
Race and neonatal respiratory morbidity in the late preterm period.种族与晚期早产儿的新生儿呼吸系统并发症。
Am J Obstet Gynecol MFM. 2021 Sep;3(5):100408. doi: 10.1016/j.ajogmf.2021.100408. Epub 2021 May 28.
3
Racial Bias in Pulse Oximetry Measurement.脉搏血氧饱和度测量中的种族偏见。
N Engl J Med. 2020 Dec 17;383(25):2477-2478. doi: 10.1056/NEJMc2029240.
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Adverse neonatal outcomes and house prices in London.伦敦的新生儿不良结局与房价
J Perinat Med. 2018 Dec 19;47(1):99-105. doi: 10.1515/jpm-2017-0397.
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Racial/ethnic differences in preterm perinatal outcomes.早产围产期结局的种族/民族差异。
Am J Obstet Gynecol. 2017 Mar;216(3):306.e1-306.e12. doi: 10.1016/j.ajog.2016.11.1026. Epub 2016 Nov 16.
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Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development.优化晚期早产儿(近足月儿)的护理与预后:美国国立儿童健康与人类发展研究所主办研讨会综述
Pediatrics. 2006 Sep;118(3):1207-14. doi: 10.1542/peds.2006-0018.
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The genetic determinants of the CYP3A5 polymorphism.CYP3A5基因多态性的遗传决定因素。
Pharmacogenetics. 2001 Dec;11(9):773-9. doi: 10.1097/00008571-200112000-00005.