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股骨颈骨折手术后的肺栓塞:五年死亡率的关键预测因素

Pulmonary Embolism Post-Femoral Neck Fracture Surgery: A Critical Predictor of Five-Year Mortality.

作者信息

Atzmon Ran, Dubin Jeremy, Shemesh Shai, Tamir Eran, Yaacobi Eyal, Palmanovich Ezequiel, Drexler Michael, Ohana Nissim

机构信息

Department of Orthopaedic Surgery, Affiliated With the Faculty of Health and Science and Ben Gurion University, Assuta Medical Center, Ashdod, Israel.

Department of Orthopaedic Surgery, Tel Aviv Medical Center, Affiliated With the Faculty of Health, Tel Aviv University, Tel Aviv, Israel.

出版信息

Geriatr Orthop Surg Rehabil. 2024 Sep 23;15:21514593241284731. doi: 10.1177/21514593241284731. eCollection 2024.

Abstract

OBJECTIVES

This study examines the impact of pulmonary embolism (PE) on mortality among patients with femoral neck fractures, exploring the predictive value of preoperative PE for postoperative occurrences and associated mortality over a 5-year follow-up period.

METHODS

We analyzed 2256 patients over 60 years old admitted with femoral neck fractures, focusing on those who developed DVT or PE postoperatively. Surgical intervention aimed within 48 hours without pharmacological thromboprophylaxis, utilizing mechanical prophylaxis instead. Postoperative management included Enoxaparin administration. Data analysis employed SPSS 21, with chi-squared tests, T-tests, and multivariate logistic regression to explore mortality and PE incidence.

RESULTS

PE was diagnosed in 1.4% of patients, with a notable mortality contrast between patients with PE (87%) and those without (59.7%) over 5 years. A history of preoperative PE emerged as a significant risk factor for postoperative PE. Despite surgical variations, no significant correlation was found between surgery type and PE incidence. Early postoperative weight-bearing and institutional rehabilitation did not significantly alter PE incidence rates.

CONCLUSIONS

The study underscores the significant mortality risk associated with preoperative PE in femoral neck fracture patients. It highlights the necessity for vigilant PE risk assessment and management, challenging assumptions about the protective role of early mobility and rehabilitation in PE incidence. Further research is essential to refine patient care strategies and improve outcomes.

摘要

目的

本研究探讨肺栓塞(PE)对股骨颈骨折患者死亡率的影响,探究术前PE在5年随访期内对术后发生情况及相关死亡率的预测价值。

方法

我们分析了2256例60岁以上因股骨颈骨折入院的患者,重点关注术后发生深静脉血栓(DVT)或PE的患者。手术干预目标在48小时内,不进行药物预防,而是采用机械预防。术后管理包括给予依诺肝素。数据分析采用SPSS 21,通过卡方检验、T检验和多因素逻辑回归来探究死亡率和PE发生率。

结果

1.4%的患者被诊断为PE, 在5年期间,有PE的患者(87%)与无PE的患者(59.7%)死亡率存在显著差异。术前PE病史是术后PE的一个重要危险因素。尽管手术方式不同,但未发现手术类型与PE发生率之间存在显著相关性。术后早期负重和机构康复并未显著改变PE发生率。

结论

该研究强调了股骨颈骨折患者术前PE相关的显著死亡风险。它突出了对PE风险进行警惕评估和管理的必要性,对早期活动和康复在PE发生率中起保护作用的假设提出了挑战。进一步的研究对于完善患者护理策略和改善预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30bf/11425733/8a2a04d2bf14/10.1177_21514593241284731-fig1.jpg

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