Department of Internal Medicine, Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Postgrad Med J. 2019 Aug;95(1126):420-424. doi: 10.1136/postgradmedj-2018-135995. Epub 2019 Jan 21.
To evaluate if imaging studies such as CT pulmonary angiography (CTPA) or ventilation-perfusion (V/Q) scan are ordered according to the current guidelines for the diagnosis of pulmonary embolism (PE).
We performed a retrospective observational cohort study in all adult patients who presented to the Sparrow Hospital Emergency Department from January 2014 to December 2016 and underwent CTPA or V/Q scan. We calculated the Wells' score retrospectively, and d-dimer values were used to determine if the imaging study was justified.
A total of 8449 patients underwent CTPA (93%) or V/Q scan (7%), among which 142 (1.7%) patients were diagnosed with PE. The Wells' criteria showed low probabilities for PE in 96 % and intermediate or high probabilities in 4 % of total patients. Modified Wells' criteria demonstrated PE unlikely in 99.6 % and PE likely in 0.4 % of total patients. D-dimer was obtained in only 37 % of patients who were unlikely to have a PE or had a low score on Wells' criteria. Despite a low or unlikely Wells' criteria score and normal d-dimer levels, 260 patients underwent imaging studies, and none were diagnosed with PE.
More than 99 % of CTPA or V/Q scans were negative in our study. This suggests extraordinary overutilisation of the imaging methods. D-dimer, recommended in patients with low to moderate risk, was ordered in only one-third of patients. Much greater emphasis of current guidelines is needed to avoid inappropriate utilisation of resources without missing diagnosis of PE.
评估 CT 肺动脉造影(CTPA)或通气灌注(V/Q)扫描等影像学检查是否按照当前肺栓塞(PE)诊断指南进行。
我们对 2014 年 1 月至 2016 年 12 月期间在 Sparrow 医院急诊科就诊并接受 CTPA 或 V/Q 扫描的所有成年患者进行了回顾性观察队列研究。我们回顾性计算了 Wells 评分,并用 D-二聚体值来确定影像学检查是否合理。
共有 8449 例患者接受了 CTPA(93%)或 V/Q 扫描(7%),其中 142 例(1.7%)患者被诊断为 PE。Wells 标准显示,96%的患者 PE 可能性低,4%的患者 PE 可能性中或高。改良 Wells 标准显示,99.6%的患者 PE 不太可能,0.4%的患者 PE 很可能。只有 37%的不太可能患有 PE 或 Wells 评分较低的患者获得了 D-二聚体检测结果。尽管 Wells 标准评分低或不太可能,且 D-二聚体水平正常,但仍有 260 例患者接受了影像学检查,均未诊断为 PE。
在我们的研究中,超过 99%的 CTPA 或 V/Q 扫描结果为阴性。这表明影像学方法的过度使用。建议在低至中度风险的患者中使用 D-二聚体,但只有三分之一的患者进行了检测。为避免资源的不当使用而不遗漏 PE 的诊断,需要更加重视当前的指南。