Atici Ali Emre, Ozocak Ayşegul Bahar, Kayaci Ayse Eren, Ozturk Ecem Guclu, Kararmaz Alper, Yegen Sevket Cumhur
Faculty of Medicine Pendik Education and Research Hospital Department of General Surgery, Marmara University, 34899, Pendik, Istanbul, Turkey.
Faculty of Medicine, Department of Anesthesiology, Marmara University, Pendik Education and Research Hospital, 34899, Pendik, Istanbul, Turkey.
Langenbecks Arch Surg. 2024 Sep 27;409(1):291. doi: 10.1007/s00423-024-03482-x.
Delayed gastric emptying (DGE) is one of the most common reasons for morbidity after pancreatoduodenectomy. The technical characteristics of anastomosis that could be affected by surgeon may offer a relevant chance to improve postoperative DGE rates. We investigated the effect of a technical modification of gastrojejunostomy after the classical pancreaticoduodenectomy on DGE.
A total of 161 patients underwent classical pancreaticoduodenectomy (with 20-40 percent antrectomy) due to pancreatic adenocarcinoma at the Department of General Surgery, Marmara University, School of Medicine Hospital, from February 2019 to May 2023, and those who met the inclusion criteria were enrolled. One hundred twenty patients had undergone classical end-to-side gastrojejunostomy (Classical GJ group), and 41 had undergone Marmara-Yegen cutting side-to-side gastrojejunostomy (M-Yc group). DGE was defined according to the International Working Group on Pancreatic Surgery, and postoperative DGE rates of both groups were compared. In addition, multivariate analysis was performed to identify possible independent predictive factors for DGE.
The total incidence of DGE was 31% in the Classical GJ group and 17% in the (M-Yc group). Although there was no significant difference between the groups regarding DGE and DGE grades (p = 0.1), DGE was distinctly lower in the M-Yc GJ group. In multi-variant analysis, Clavien-Dindo grade 3a and above postoperative complication was determined as independent predictors for DGE.
We tried to explain the mechanism of DGE in terms of anatomical configuration. The incidence and severity of DGE decreased in patients who underwent M-Yc GJ.
胃排空延迟(DGE)是胰十二指肠切除术后发病的最常见原因之一。可能受外科医生影响的吻合技术特点可能为提高术后DGE发生率提供相关机会。我们研究了经典胰十二指肠切除术后胃空肠吻合术的技术改良对DGE的影响。
2019年2月至2023年5月,马尔马拉大学医学院医院普通外科共有161例因胰腺腺癌接受经典胰十二指肠切除术(切除20%-40%胃窦)的患者,符合纳入标准的患者被纳入研究。120例患者接受了经典的端侧胃空肠吻合术(经典GJ组),41例接受了马尔马拉-耶根切割侧侧胃空肠吻合术(M-Yc组)。根据国际胰腺手术工作组的定义确定DGE,并比较两组的术后DGE发生率。此外,进行多因素分析以确定DGE可能的独立预测因素。
经典GJ组DGE的总发生率为31%,(M-Yc组)为17%。虽然两组在DGE和DGE分级方面无显著差异(p = 0.1),但M-Yc GJ组的DGE明显较低。在多因素分析中,Clavien-Dindo 3a级及以上术后并发症被确定为DGE的独立预测因素。
我们试图从解剖结构方面解释DGE的机制。接受M-Yc GJ的患者中DGE的发生率和严重程度降低。