Zhang Yaping, Tian Yinting, Wang Zheyuan, Zhang Yawu, Wang Gennian
Department of Hepatopathy, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China.
Department of General Surgery, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Linxia Road, Chengguan District, Lanzhou, 730030, Gansu, China.
Discov Oncol. 2024 Sep 27;15(1):481. doi: 10.1007/s12672-024-01377-3.
Over the past three decades, endoplasmic reticulum (ER) stress has gained considerable attention in the field of hepatocellular carcinoma (HCC) with an increasing number of publications. It is crucial to reveal the global status, research hotspots and future research trends of ER stress in HCC. The aim of this study is to analyze the publications related to ER stress in HCC through bibliometric analysis in order to better understand the current status of ER stress research in HCC and to identify potential new research directions.
In this study, articles and reviews on ER stress in HCC up to December 31, 2023 were searched and downloaded from the Science Citation Index-Expanded (SCIE) of the Web of Science Core Collection (WoSCC), Pubmed, Scopus and Embase databases. Using CiteSpace 6.2.R6, VOSviewer 1.6.19, Scimago Graphica and Microsoft Office Excel 2019, the knowledge networks of a variety of countries, regions, authors, references, keywords and journals were analyzed.
A total of 1239 publications were retrieved, including 843 articles and 396 review articles. The number of global publications is increasing every year, with the majority of publications coming from China and the USA. Ih-Jen Su, Wenya Huang and Wei Wei are the top 3 prolific authors. "Progression", "inflammation", "cell cycle arrest", "metabolism", "snsignaling pathways", "pathogenesis" and "non-alcoholic fatty liver disease" have emerged as research hotspots in recent years. The journal with the greatest co-citation is Hepatology.
Based on current global trends, the total number of publications on ER stress in HCC research will continue to increase, but there is a need for more cooperation between authors and countries/regions. ER stress in HCC will continue to be a research priority.
Based on current global trends, the total number of publications on ER stress in HCC research will continue to increase, but there is a need for more cooperation between authors and countries/regions. ER stress in HCC will continue to be a research priority.
在过去三十年中，内质网（ER）应激在肝细胞癌（HCC）领域受到了越来越多的关注，相关出版物数量不断增加。揭示HCC中ER应激的全球研究现状、热点及未来研究趋势至关重要。本研究旨在通过文献计量分析来剖析与HCC中ER应激相关的出版物，以便更好地了解HCC中ER应激研究的现状，并确定潜在的新研究方向。
本研究检索并下载了截至2023年12月31日Web of Science核心合集（WoSCC）的科学引文索引扩展版（SCIE）、Pubmed、Scopus和Embase数据库中关于HCC中ER应激的文章和综述。使用CiteSpace 6.2.R6、VOSviewer 1.6.19、Scimago Graphica和Microsoft Office Excel 201�，对多个国家、地区、作者、参考文献、关键词和期刊的知识网络进行了分析。
共检索到1239篇出版物，其中包括843篇文章和396篇综述文章。全球出版物数量逐年增加，大多数出版物来自中国和美国。苏怡仁、黄文娅和魏巍是发文量排名前三的高产作者。“进展”“炎症”“细胞周期阻滞”“代谢”“信号通路”“发病机制”和“非酒精性脂肪性肝病”已成为近年来的研究热点。被引频次最高的期刊是《肝脏病学》。
基于当前全球趋势，HCC研究中关于ER应激的出版物总数将继续增加，但作者之间以及国家/地区之间需要更多合作。HCC中的ER应激将继续是研究重点。
基于当前全球趋势，HCC研究中关于ER应激的出版物总数将继续增加，但作者之间以及国家/地区之间需要更多合作。HCC中的ER应激将继续是研究重点。
