与玻璃体内注射法西单抗相关的闭塞性视网膜血管炎。
Occlusive retinal vasculitis associated with intravitreal Faricimab injections.
作者信息
Reichel Felix F, Kiraly Peter, Vemala Roopa, Hornby Stella, De Silva Samantha R, Fischer M Dominik
机构信息
Centre for Ophthalmology, University Eye Hospital, University Hospital Tübingen, Tübingen, Germany.
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
出版信息
J Ophthalmic Inflamm Infect. 2024 Sep 27;14(1):45. doi: 10.1186/s12348-024-00429-7.
PURPOSE
We describe a case of occlusive vasculitis associated with intravitreal Faricimab (Vabysmo) injections.
METHODS
A retrospective case report.
RESULTS
A 52-year old man treated with monthly Faricimab injections for diabetic macula oedema presented with sudden reduced vision, new retinal hemorrhages, significant retinal vascular occlusions and ischemia. After screening for differential diagnoses was unremarkable, the patient was treated with oral and intravitreal steroid therapy under which the occlusive vasculitis was stabilized.
CONCLUSION
Occlusive vasculitis, though rare, is a potential complication of Faricimab therapy. Comprehensive reporting and large-scale analyses are essential to better understand and manage this adverse event.
目的
我们描述一例与玻璃体内注射法西单抗（Vabysmo）相关的闭塞性血管炎病例。
方法
一项回顾性病例报告。
结果
一名52岁男性因糖尿病性黄斑水肿接受每月一次的法西单抗注射治疗，出现视力突然下降、新的视网膜出血、显著的视网膜血管闭塞和缺血。在排除鉴别诊断无异常后，该患者接受了口服和玻璃体内类固醇治疗，在此治疗下闭塞性血管炎病情稳定。
结论
闭塞性血管炎虽然罕见，但却是法西单抗治疗的潜在并发症。全面报告和大规模分析对于更好地理解和管理这一不良事件至关重要。
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