Sankar Sakthimurugan, N Raadhika Shree, Anbarasan Subagar, P Jayaganesh
Department of Otorhinolaryngology and Head & Neck Surgery, Saveetha Medical College and Hospital, SIMATS, Chennai, Tamil Nadu, India.
Department of Pathology, Saveetha Medical College and Hospital, SIMATS, Chennai, Tamil Nadu, India.
Ear Nose Throat J. 2024 Sep 27:1455613241285668. doi: 10.1177/01455613241285668.
Granular cell tumors (GCTs) are uncommon neoplasms, often originating from Schwann cells, with granular cytoplasm being a hallmark feature. Laryngeal GCTs, comprising 3% to 10% of cases, present diagnostic challenges due to their resemblance to squamous cell carcinoma. We present a case of a 46-year-old male with throat pain, diagnosed with a laryngeal GCT. Histopathological examination and immunohistochemistry confirmed the diagnosis. Laryngeal GCTs typically manifest as small, firm submucosal nodules, posing challenges in differentiation from vocal fold polyps. Diagnosis relies on histological examination, with characteristic features including eosinophilic granular cytoplasm and positive staining for specific markers. Malignant transformation, though rare, necessitates vigilant monitoring and accurate diagnosis. Treatment involves complete surgical excision with long-term follow-up to detect recurrence. This case underscores the importance of awareness and accurate diagnosis in managing laryngeal GCTs, ensuring timely intervention and optimal patient outcomes.
颗粒细胞瘤(GCTs)是一种罕见的肿瘤,通常起源于施万细胞,其标志性特征是细胞质呈颗粒状。喉颗粒细胞瘤占病例的3%至10%,由于其与鳞状细胞癌相似,给诊断带来了挑战。我们报告一例46岁男性咽喉疼痛患者,诊断为喉颗粒细胞瘤。组织病理学检查和免疫组织化学确诊了该病例。喉颗粒细胞瘤通常表现为小的、质地坚硬的黏膜下结节,与声带息肉的鉴别存在挑战。诊断依赖于组织学检查,其特征性表现包括嗜酸性颗粒状细胞质和特定标志物的阳性染色。尽管恶性转化罕见,但仍需密切监测和准确诊断。治疗包括完整的手术切除,并进行长期随访以检测复发情况。该病例强调了在管理喉颗粒细胞瘤时提高认识和准确诊断的重要性,以确保及时干预和患者获得最佳治疗效果。