Hu Dandan, Cong Xiangguo, Gao Beibei, Wu Ying, Shen Qiong, Chen Lei
Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Endocr Connect. 2024 Nov 14;13(12). doi: 10.1530/EC-24-0412. Print 2024 Dec 1.
Evidence has demonstrated that visceral fat area (VFA) and subcutaneous fat area (SFA) have different influences on cardiovascular disease (CVD) risk in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the relationship between the visceral fat area (VFA), the subcutaneous fat area (SFA) ratio (V/S), and carotid atherosclerosis (CAS) in patients with T2DM.
From January 2018 to May 2023, 1838 patients with T2DM admitted to the National Metabolic Management Centre in our hospital were assigned to two groups based on comorbid CAS. Dual bioelectrical impedance analysis was used to measure the VAF and SFA, and the V/S was calculated. Patient characteristics and serum biochemical indices were compared between groups. Factors influencing comorbid CAS were determined, and correlations between V/S and other clinical indices were analyzed.
The group with comorbid CAS included 858 individuals and 980 without comorbid CAS. Those with comorbid CAS were older and had a longer disease duration, more significant systolic blood pressure, and greater V/S. The proportions of patients with comorbid hypertension increased significantly with the V/S ratio. The V/S ratio positively correlated with triglyceride (TG), low-density lipoprotein cholesterol levels, and waist circumference. According to binary logistic regression analysis, V/S was an independent risk factor for CAS.
Elevated V/S is an independent risk factor for CAS in patients with T2DM.
有证据表明，内脏脂肪面积（VFA）和皮下脂肪面积（SFA）对2型糖尿病（T2DM）患者的心血管疾病（CVD）风险有不同影响。我们旨在研究T2DM患者的内脏脂肪面积（VFA）、皮下脂肪面积与内脏脂肪面积比值（V/S）和颈动脉粥样硬化（CAS）之间的关系。
2018年1月至2023年5月，我院国家代谢管理中心收治的1838例T2DM患者根据是否合并CAS分为两组。采用双频生物电阻抗分析测量VAF和SFA，并计算V/S。比较两组患者的特征和血清生化指标。确定影响合并CAS的因素，并分析V/S与其他临床指标之间的相关性。
合并CAS组858例，未合并CAS组980例。合并CAS者年龄较大，病程较长，收缩压更高，V/S更大。合并高血压患者的比例随V/S比值显著增加。V/S比值与甘油三酯（TG）、低密度脂蛋白胆固醇水平和腰围呈正相关。二元logistic回归分析显示，V/S是CAS的独立危险因素。
V/S升高是T2DM患者发生CAS的独立危险因素。
