Department of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong medicine and Health Key Laboratory of Emergency Medicine, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Jinan, Shandong, China.
Medicine (Baltimore). 2024 Sep 27;103(39):e39417. doi: 10.1097/MD.0000000000039417.
Current studies have not clarified the relationship between riboflavin intake and all-cause mortality in patients with chronic kidney disease (CKD). The aim of this study is to investigate whether there is an association between riboflavin intake and the risk of all-cause mortality in patients with CKD. This was a retrospective cohort study with data extracted from the National Health and Nutrition Examination Survey (NHANES). The study was conducted using Cox regression analysis to calculate hazard ratio (HR) and 95% confidence interval (CI) to assess the association between riboflavin intake and risk of all-cause mortality. Subgroup analyses were performed regarding gender, CKD stage, hypertension, hyperlipidemia and cardiovascular disease (CVD). A total of 3750 patients were ultimately included in the analyses. After excluding potential confounders, lower intake of riboflavin was associated with the higher risk of all-cause mortality (Q1: HR = 1.33, 95% CI: 1.05-1.69). The similar association was also found in patients at mild/moderate stage (HR = 1.32, 95% CI: 1.05-1.66), in female (HR = 1.35, 95% CI: 1.01-1.81), with hypertension (HR = 1.37, 95% CI: 1.07-1.75), CVD (HR = 1.48, 95% CI: 1.08-2.03), and dyslipidemia (HR = 1.29, 95% CI: 1.01-1.66). This study found the association between low riboflavin intake and high risk of all-cause mortality, indicating a potential beneficial role of riboflavin in CKD patients.
目前的研究尚未阐明核黄素摄入量与慢性肾脏病（CKD）患者全因死亡率之间的关系。本研究旨在探讨核黄素摄入量与 CKD 患者全因死亡率风险之间是否存在关联。这是一项回顾性队列研究，数据来自国家健康和营养调查（NHANES）。研究采用 Cox 回归分析计算风险比（HR）和 95%置信区间（CI），以评估核黄素摄入量与全因死亡率风险之间的关系。根据性别、CKD 分期、高血压、高血脂和心血管疾病（CVD）进行了亚组分析。最终共有 3750 名患者纳入分析。在排除潜在混杂因素后，较低的核黄素摄入量与全因死亡率风险增加相关（Q1：HR=1.33，95%CI：1.05-1.69）。在轻度/中度 CKD 患者中也发现了类似的相关性（HR=1.32，95%CI：1.05-1.66），在女性（HR=1.35，95%CI：1.01-1.81）、高血压（HR=1.37，95%CI：1.07-1.75）、CVD（HR=1.48，95%CI：1.08-2.03）和血脂异常（HR=1.29，95%CI：1.01-1.66）患者中也发现了类似的相关性。本研究发现低核黄素摄入与全因死亡率风险增加之间存在关联，表明核黄素在 CKD 患者中可能具有潜在的有益作用。
