[Indication of the vasomotor effects of secretin and cholecystokinin by changes in blood gas concentration?].

The assumption that secretin has a general vascular effect led to an investigation of the blood gas level in the peripheral veins and the acid/base balance under the influence of secretin (1 CU/Kg/h, 0 to 120 mins) and cholecystokinin (1 IU/Kg/h, 60 to 120 mins) in a group of 10 volunteers. Six of the volunteers were subjected to a randomised crossover study under NaCl infusion. With a secretin infusion alone (0 to 60 mins) there was a transient, significant rise in PO2 (p less than 0.01) and oxygen saturation (p less than 0.05), which was no longer detectable after 60 minutes (p greater than 0.05). With an additional administration of cholecystokinin (60 to 120 mins) and in the follow-up phase of observation (120 to 180 mins) there was a significant fall in both parameters (120 min.: p less than 0.05, 180 min.: p less than 0.01). PCO2, HCO-3 and pH remained unaffected. The isolated increase in PO2 and O2 saturation may be attributed to vasodilation induced by secretin. The drop in both parameters under the influence of an additional infusion of cholecystokinin and in the follow-up phase of observation is linked to a possible vascular effect of cholecystokinin.