Department of Pediatrics, Children's Medical Center, Peking University First Hospital.
Department of Pediatrics, Children's Medical Center, Peking University First Hospital.
Clin Neurophysiol. 2024 Nov;167:192-197. doi: 10.1016/j.clinph.2024.09.016. Epub 2024 Sep 19.
This study aimed to analyze and summarize the characteristics of generalized paroxysmal fast activity (GPFA) via electroencephalography (EEG) in patients with epilepsy with eyelid myoclonia (EEM) and to determine its relationship with clinical outcome.
Patients with EEM were selected from our EEG database. The collected data included detailed clinical information, factors that triggered GPFA, and the relationship between GPFA and eyelid myoclonia seizures. The clinical data and EEG characteristics of patients with and without GPFA were compared.
Forty-seven patients with EEM were identified according to the clinical criteria, of whom 18 (38.3%) exhibited GPFA. GPFA can occur ictally or interictally. The difference in the response to antiseizure medication (ASM) between EEM patients with and without GPFA suggested that patients who had GPFA on EEG might have easier seizure control.
In our study, 38.3% of EEM patients had GPFA on EEG. GPFA is an EEG pattern in individuals with EEM that can cause eyelid myoclonia. EEM patients with GPFA on their EEG had easier seizure control than those without GPFA.
This study summarized the incidence and electroclinical features of GPFA in a cohort of patients with EEM.
本研究旨在通过脑电图（EEG）分析和总结癫痫伴眼睑肌阵挛（EEM）患者的泛发性阵发性快活动（GPFA）特征，并确定其与临床结果的关系。
从我们的 EEG 数据库中选择 EEM 患者。收集的数据包括详细的临床信息、引发 GPFA 的因素以及 GPFA 与眼睑肌阵挛发作之间的关系。比较了有和没有 GPFA 的患者的临床数据和 EEG 特征。
根据临床标准确定了 47 例 EEM 患者，其中 18 例（38.3%）存在 GPFA。GPFA 可发作性或非发作性出现。抗癫痫药物（ASM）反应的差异表明 EEG 上有 GPFA 的 EEM 患者可能具有更容易控制的癫痫发作。
在我们的研究中，38.3%的 EEM 患者的 EEG 上存在 GPFA。GPFA 是 EEM 个体中的一种 EEG 模式，可引起眼睑肌阵挛。EEG 上有 GPFA 的 EEM 患者的癫痫发作控制比没有 GPFA 的患者更容易。
本研究总结了 EEM 患者队列中 GPFA 的发生率和电临床特征。
