College of Pharmacy, Shenzhen Technology University, Shenzhen, China.
Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Biochem Biophys Res Commun. 2024 Nov 12;733:150733. doi: 10.1016/j.bbrc.2024.150733. Epub 2024 Sep 24.
Obesity is a significant global public health issue linked to numerous chronic diseases, including diabetes, cardiovascular conditions, and various cancers. The vacuolar H + ATPase, a multi-subunit enzyme complex involved in maintaining pH balance, has been implicated in various health conditions, including obesity-related diseases.
This study conducts a comprehensive analysis of V-ATPase subunits' roles in adipogenesis within the context of obesity, using knockdown and RNAseq technologies.
This study conducts a comprehensive analysis of V-ATPase subunits' roles in adipogenesis, highlighting specific subunits, v0d2 and v1a, which show significant expression alterations. Our findings reveal that v1a plays a crucial role in adipocyte differentiation through pathways related to steroid and cholesterol metabolism.
This study provides a comprehensive analysis of the roles played by V-ATPase subunits in adipogenesis and finds the critical role of V-ATPase subunits, particularly v1a, in the differentiation of adipocytes and their potential impact on obesity.
肥胖是一个全球性的重大公共卫生问题，与许多慢性疾病有关，包括糖尿病、心血管疾病和各种癌症。液泡 H + ATP 酶是一种参与维持 pH 平衡的多亚基酶复合物，与包括肥胖相关疾病在内的各种健康状况有关。
本研究使用 knockdown 和 RNAseq 技术，综合分析 V-ATPase 亚基在肥胖相关脂肪生成中的作用。
本研究综合分析了 V-ATPase 亚基在脂肪生成中的作用，突出了特定的亚基 v0d2 和 v1a，它们显示出显著的表达变化。我们的研究结果表明，v1a 通过与类固醇和胆固醇代谢相关的途径，在脂肪细胞分化中发挥关键作用。
本研究全面分析了 V-ATPase 亚基在脂肪生成中的作用，发现 V-ATPase 亚基，特别是 v1a，在脂肪细胞分化中起着关键作用，其对肥胖的潜在影响值得关注。
