Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Biomater Adv. 2025 Jan;166:214054. doi: 10.1016/j.bioadv.2024.214054. Epub 2024 Sep 23.
Spinal cord injury (SCI) leaves a temporary or enduring motor, sensory, and autonomic function loss, significantly impacting the patient's quality of life. Given their biocompatibility, bioactivity, and tunable attributes, three-dimensional scaffolds frequently employ carbohydrates to facilitate spinal cord regeneration. These scaffolds have also been engineered to be novel local delivery platforms that present distinct advantages in the targeted transportation of drug candidates to the damaged spinal cord, ensuring the right dosage and duration of administration. Neurotrophic factors have emerged as promising therapeutic candidates, preserved neuron survival and encouraged severed axons repair, although their local and continuous delivery is believed to produce considerable spinal cord rehabilitation. This study aims to discuss breakthroughs in scaffold engineering, exploiting carbohydrates as an essential part of their structure, and highlight their impact on spinal cord regeneration and sustained neurotrophic factors delivery to treat SCI.
脊髓损伤 (SCI) 会导致暂时或永久性的运动、感觉和自主功能丧失，严重影响患者的生活质量。由于其生物相容性、生物活性和可调属性，三维支架经常使用碳水化合物来促进脊髓再生。这些支架还被设计成新型的局部递送平台，在将候选药物靶向递送到受损的脊髓方面具有明显的优势，确保了正确的剂量和给药时间。神经营养因子已成为有前途的治疗候选物，它们可以保留神经元的存活并促进切断的轴突修复，尽管人们认为局部和持续的递送会产生相当大的脊髓康复效果。本研究旨在讨论支架工程的突破，利用碳水化合物作为其结构的重要组成部分，并强调它们对脊髓再生和持续神经营养因子递送治疗 SCI 的影响。
