慢性炎症和癌症中的普遍存在和组织特异性成纤维细胞。
Universal and tissue-specific fibroblasts in chronic inflammation and cancer.
机构信息
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; CIFAR Macmillan Multi-scale Human Programme, CIFAR, Toronto, Canada.
出版信息
Cancer Cell. 2024 Oct 14;42(10):1648-1650. doi: 10.1016/j.ccell.2024.08.022. Epub 2024 Sep 26.
In this issue of Cancer Cell, Gao et al. map fibroblast diversity across tumors and chronic inflammatory tissues. The authors uncover universal fibroblast subtypes such as LRRC15 and MMP1 myofibroblasts along with specialized tissue-specific subtypes. They reveal cellular roles of fibroblasts in immunosuppression through stromal niches and cell-cell interactions.
在本期《癌细胞》中，高等人绘制了肿瘤和慢性炎症组织中纤维母细胞的多样性图谱。作者揭示了普遍存在的纤维母细胞亚型，如 LRRC15 和 MMP1 肌成纤维细胞，以及专门的组织特异性亚型。他们揭示了纤维母细胞通过基质龛和细胞间相互作用在免疫抑制中的细胞作用。
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