Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ, USA.
Departments of Hematology and Medical Oncology, Breast Cancer Center, Women's Cancer Program, Cooper University Health Care, Camden, NJ, USA; MD Anderson Cancer Center at Cooper, Camden, NJ, USA.
Life Sci. 2024 Nov 15;357:123082. doi: 10.1016/j.lfs.2024.123082. Epub 2024 Sep 25.
Amid the dynamic field of cancer research, various targeted therapies have proven crucial in combating breast cancer, the most prevalent cancer among women globally. Triple Negative Breast Cancer (TNBC) stands out from other types of breast cancer due to the absence of three key receptors on the cell surface (progesterone, estrogen, and HER2). Researchers are working on finding ways to address TNBC's elusive biomarkers and minimize the damage caused by the disease through treatments like chemotherapies and targeted pathway receptors. One connection that should receive more attention is the link between TNBC and obesity. Obesity is defined as consuming significantly more energy than is expended, resulting in a high BMI. Moreover, obesity fosters a cancer-friendly environment characterized by inflammation, elevated levels of hormones, proteins, and signaling that activate pathways promoting cancer. Non-Hispanic black women have experienced notable disparities in TNBC rates. Various factors have led to the higher incidence and poorer outcomes of TNBC in non-Hispanic black women. This detailed review explores the complex relationship between obesity and TNBC, examining how the two disorders are connected in terms of disparities and offering a glimpse into future research and interventions.
在癌症研究的动态领域中，各种靶向疗法已被证明对治疗乳腺癌至关重要，乳腺癌是全球女性最常见的癌症。三阴性乳腺癌（TNBC）与其他类型的乳腺癌不同，因为其细胞表面缺乏三种关键受体（孕激素、雌激素和 HER2）。研究人员正在寻找方法来解决 TNBC 难以捉摸的生物标志物，并通过化疗和靶向途径受体等治疗方法来最小化疾病造成的损害。一个应该得到更多关注的联系是 TNBC 和肥胖之间的联系。肥胖的定义是消耗的能量明显多于消耗的能量，导致 BMI 较高。此外，肥胖会导致炎症、激素、蛋白质和信号水平升高，从而促进促进癌症的途径激活，形成有利于癌症的环境。非西班牙裔黑人女性在 TNBC 发病率方面存在显著差异。各种因素导致非西班牙裔黑人女性 TNBC 的发病率更高，预后更差。本详细综述探讨了肥胖与 TNBC 之间的复杂关系，研究了这两种疾病在差异方面的联系，并对未来的研究和干预措施进行了展望。
