Nakagawa S, Kobayashi T, Nakao M, Toyoda K, Mishina T, Miyakoda K
Hinyokika Kiyo. 1985 Jul;31(7):1227-31.
FT-207 and 5-FU (1,200 mg) were administered intravesically to 5 mongrel dogs, and their concentration in the serum and bladder wall was measured. The serum concentration was high in both groups because their molecular weights are less than 200. The serum concentration of FT-207 was approximately 40 times higher than that of 5-FU. This difference may be due to the fact that non-ionized molecules in FT-207 account for more than 80% but those in 5-FU account for less than 10%.
将FT - 207和5 - 氟尿嘧啶（1200毫克）膀胱内给药于5只杂种犬，并测定它们在血清和膀胱壁中的浓度。两组的血清浓度都很高，因为它们的分子量小于200。FT - 207的血清浓度大约是5 - 氟尿嘧啶的40倍。这种差异可能是由于FT - 207中非离子化分子占80%以上，而5 - 氟尿嘧啶中的非离子化分子占不到10%。
