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从疼痛程度到疼痛体验:重新定义急性疼痛评估以增强对慢性术后疼痛的理解。

From pain level to pain experience: redefining acute pain assessment to enhance understanding of chronic postsurgical pain.

机构信息

Department of Anaesthesiology and Intensive Care Medicine, Nice University Hospital, Nice, France.

Department of Medical Statistics, and Epidemiology, Montpellier University Hospital, Montpellier, France; Debrest Institute of Epidemiology and Public Health IDESP, UMR INSERM, University of Montpellier, Montpellier, France; Department of Anaesthesiology and Critical Care Medicine, Lapeyronie University Hospital, and Montpellier NeuroSciences Institute, Inserm U 1051, Montpellier, France.

出版信息

Br J Anaesth. 2024 Nov;133(5):1021-1027. doi: 10.1016/j.bja.2024.08.003. Epub 2024 Sep 26.

Abstract

BACKGROUND

Chronic postsurgical pain (CPSP) significantly impairs quality of life and poses a substantial healthcare burden, affecting up to a quarter of patients undergoing surgery. Although acute pain is recognised as a predictor for CPSP development, the role of patient experience remains underexplored. This study examines the predictive value of patient experience alongside traditional risk factors for CPSP after orthopaedic surgery.

METHODS

An exploratory analysis was conducted on 294 patients from a multicentre randomised clinical trial comparing continuous perineural analgesia and single-injection nerve block in ambulatory orthopaedic surgeries. Patient experience was assessed using the Evaluation du Vecu de l'Anesthésie Générale (EVAN-G) validated questionnaire. Factors associated with CPSP at 90 days after surgery were identified through univariate and multivariate analyses, incorporating patient-reported outcomes and classical variables.

RESULTS

Out of 219 patients with complete data, 63 (29%) developed CPSP at day 90. Multivariate analysis revealed a poor pain experience, as assessed by the pain dimension of EVAN-G on postoperative day 2, as an independent predictor of CPSP (odds ratio 6.45, 95% confidence interval 1.65-25.26, P<0.01). Poor pain experience was associated with an augmented risk of CPSP.

CONCLUSIONS

This study underscores the role of patient-reported outcomes, specifically the pain experience dimension captured by the EVAN-G scale, in prediction of CPSP 90 days after surgery. It suggests a shift from conventional assessments of pain intensity to a comprehensive understanding of pain experience, advocating for tailored pain management approaches that could reduce chronic pain, thereby improving patient quality of life and functional recovery.

摘要

背景

慢性术后疼痛(CPSP)显著降低生活质量,并对医疗保健造成重大负担,影响多达四分之一接受手术的患者。尽管急性疼痛被认为是 CPSP 发展的预测因素,但患者体验的作用仍未得到充分探索。本研究探讨了患者体验与骨科手术后 CPSP 相关的传统危险因素的预测价值。

方法

对一项多中心随机临床试验中的 294 名患者进行了探索性分析,该试验比较了连续外周神经阻滞镇痛与单次神经阻滞在门诊骨科手术中的应用。使用经验证的 Evaluation du Vecu de l'Anesthésie Générale(EVAN-G)问卷评估患者体验。通过单变量和多变量分析,结合患者报告的结局和经典变量,确定与术后 90 天 CPSP 相关的因素。

结果

在 219 名具有完整数据的患者中,63 名(29%)在第 90 天发生 CPSP。多变量分析显示,术后第 2 天 EVAN-G 疼痛维度评估的疼痛体验较差是 CPSP 的独立预测因素(优势比 6.45,95%置信区间 1.65-25.26,P<0.01)。较差的疼痛体验与 CPSP 的风险增加相关。

结论

本研究强调了患者报告的结局,特别是 EVAN-G 量表所捕捉的疼痛体验维度,在预测术后 90 天 CPSP 中的作用。它提示从疼痛强度的传统评估转变为对疼痛体验的全面理解,倡导采用个体化的疼痛管理方法,以减少慢性疼痛,从而提高患者的生活质量和功能恢复。

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