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Galectin-9 作为急性肝衰竭的新型生物标志物。

Galectin-9 as a new biomarker of acute-on-chronic liver failure.

机构信息

Hepatology Department, The Fifth Medical Center of Chinese PLA General Hospital, No. 100, Xisi Huanzhong Road, Beijing, 10039, China.

Infectious Disease Department, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 10039, China.

出版信息

Sci Rep. 2024 Sep 27;14(1):22303. doi: 10.1038/s41598-024-73397-6.

DOI:10.1038/s41598-024-73397-6
PMID:39333198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11437140/
Abstract

Galectin-9 (Gal-9) expression in patients with acute-on-chronic liver failure and its correlation with prognosis remain unclear. This study investigated the relationship between liver failure prognosis and Gal-9 expression analysis in patients with acute-on-chronic liver failure. Patients with acute-on-chronic liver failure attributable to hepatitis B and those with chronic hepatitis B were included in this single-center prospective cohort study. The Gal-9 levels in the acute-on-chronic liver failure group were significantly higher than those in the chronic hepatitis B group, and there was an upregulation of Gal-9 and T-cell immunoglobulin domain and mucin domain-3 expressions in peripheral blood T cells. Gal-9 was localized in the regenerative areas of liver tissues in patients with acute-on-chronic liver failure, co-localizing with Kupffer cells. Kaplan-Meier survival curves showed that patients with Gal-9 levels < 9.6 ng/ml had a worse prognosis, with the area under the receiver operating characteristic curve (AUC-ROC) being similar to that of the Model for End-Stage Liver Disease score. The combined ROC curve of the two had better predictive performance, with an AUC of 0.945. High Gal-9 levels in liver regenerative areas can serve as a prognostic marker, indicating a better prognosis for patients with hepatitis B virus-acute-on-chronic liver failure.

摘要

Galectin-9（Gal-9）在慢性加急性肝衰竭患者中的表达及其与预后的关系尚不清楚。本研究旨在探讨乙型肝炎相关的慢性加急性肝衰竭患者中肝衰竭预后与 Gal-9 表达分析的关系。这项单中心前瞻性队列研究纳入了乙型肝炎相关的慢性加急性肝衰竭患者。结果发现，慢性加急性肝衰竭组患者的 Gal-9 水平明显高于慢性乙型肝炎组，外周血 T 细胞中 Gal-9 和 T 细胞免疫球蛋白域和粘蛋白域-3 的表达上调。Gal-9 在慢性加急性肝衰竭患者的肝组织再生区域中定位于库普弗细胞中。生存曲线表明 Gal-9 水平<9.6ng/ml 的患者预后较差，其受试者工作特征曲线下面积（AUC-ROC）与终末期肝病模型评分相似。两者的联合 ROC 曲线具有更好的预测性能，AUC 为 0.945。高 Gal-9 水平在肝再生区域可以作为预后标志物，表明乙型肝炎病毒相关的慢性加急性肝衰竭患者的预后较好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/b706dbfc2b6a/41598_2024_73397_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/db39aa8c0323/41598_2024_73397_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/739f11546a2b/41598_2024_73397_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/f72c712268ae/41598_2024_73397_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/e0de6864ee6d/41598_2024_73397_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/b706dbfc2b6a/41598_2024_73397_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/db39aa8c0323/41598_2024_73397_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/739f11546a2b/41598_2024_73397_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/f72c712268ae/41598_2024_73397_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/e0de6864ee6d/41598_2024_73397_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c3/11437140/b706dbfc2b6a/41598_2024_73397_Fig5_HTML.jpg

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