Division of Infectious Diseases, Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea.
Sci Rep. 2024 Sep 27;14(1):22254. doi: 10.1038/s41598-024-73993-6.
Patients with diabetes mellitus (DM) are at a higher risk of infectious diseases, and exercise is an important treatment modality for DM. Despite their susceptibility to infection in diabetic patients, the association between the amount of physical activity and the incidence of infective endocarditis (IE) is unclear. We attempted to demonstrate risk reduction by physical activity in diabetic patients with IE. From the National Health Insurance database, patients with DM were verified, and the incidence of IE was investigated. The level of physical activity was categorized into < 500, 500-999, 1,000-1,499, and ≥ 1,500 metabolic equivalent task (METs) minutes/week. Cox proportional hazard models were used to analyze the relationship between incident IE and physical activity. A total of 2,603,012 patients were included in this study. The incidence rate of IE was 10.06, 9.45, 7.78, and 8.84 in < 500, 500-999, 1,000-1,499, and ≥ 1,500 METs-minutes/week groups, respectively (100,000 person/year). A significant risk reduction of incident IE was observed in the 1,000-1499 and ≥ 1,500 METs-min/week groups compared to the < 500 METs-min/week group (Hazard ratio = 0.82, 95% confidence interval [0.690-0.976], HR = 0.831, 95% CI [0.704-0.981]). An analysis of a large national cohort database demonstrated that physical exercise reduced the risk of IE in patients with DM.
患有糖尿病（DM）的患者感染传染病的风险较高，运动是 DM 的重要治疗方式。尽管糖尿病患者易感染，但体力活动量与感染性心内膜炎（IE）发病率之间的关联尚不清楚。我们试图证明患有 IE 的糖尿病患者通过体力活动可降低风险。从国家健康保险数据库中验证了患有 DM 的患者，并调查了 IE 的发病率。体力活动水平分为 <500、500-999、1,000-1,499 和 ≥1,500 代谢当量任务 (MET) 分钟/周。Cox 比例风险模型用于分析 IE 发病与体力活动之间的关系。本研究共纳入 2603012 名患者。IE 的发病率分别为 <500、500-999、1000-1499 和 ≥1500 METs-min/周组为 10.06、9.45、7.78 和 8.84（100,000 人/年）。与 <500 METs-min/周组相比，1000-1499 和 ≥1500 METs-min/周组 IE 发病的风险显著降低（危险比=0.82，95%置信区间[0.690-0.976]，HR=0.831，95%CI[0.704-0.981]）。对大型全国队列数据库的分析表明，运动可降低糖尿病患者 IE 的风险。
