Research and Development Division, Mitsubishi Corporation Life Sciences Limited, Tokyo, 100-0006, Japan.
Maruishilabo Corporation, Osaka, 531-0071, Japan.
Sci Rep. 2024 Sep 27;14(1):22163. doi: 10.1038/s41598-024-73447-z.
The oral administration of antioxidants may suppress UV-B-induced skin damage. HITHION YH-15, the extract of Torula yeast (Cyberlindnera jadinii), is rich in cysteine-containing peptides such as reduced and oxidized glutathione (GSH and GSSG), γ-glutamylcysteine (γ-Glu-Cys), and cysteinylglycine (Cys-Gly). These four constituents are termed cysteine peptides. In this study, we investigated the protective effects of cysteine peptides against UV-B in a randomized, placebo-controlled, double-blind, parallel-group study. A total of 90 healthy males and females aged 30-59 years were enrolled and randomized into two groups of 45 individuals each (cysteine peptides (48 mg/day) and placebo). Changes in UV-B-induced erythema and pigmentation were compared between groups after 5 weeks of test food intake. The minimal erythema dose (MED) significantly increased (p = 0.019) in the cysteine peptides group compared to that in the placebo group, indicating suppression of UV-B-induced erythema. ΔL value significantly increased (***p < 0.0001) in the cysteine peptides group compared to that in the placebo, indicating pigmentation suppression. We demonstrated that oral administration of cysteine peptides suppresses UV-B-induced erythema and pigmentation through multiple mechanisms. Thus, cysteine peptides may find use as nutricosmetics for maintaining skin health and well-being.UMIN Clinical Trials Registry ID: UMIN 000050157.
口服抗氧化剂可能抑制 UV-B 诱导的皮肤损伤。海特醇 YH-15，是一种从圆酵母（Cyberlindnera jadinii）中提取的物质，富含半胱氨酸肽，如还原型和氧化型谷胱甘肽（GSH 和 GSSG）、γ-谷氨酰半胱氨酸（γ-Glu-Cys）和半胱氨酰甘氨酸（Cys-Gly）。这四种成分被称为半胱氨酸肽。在这项研究中，我们在一项随机、安慰剂对照、双盲、平行组研究中，调查了半胱氨酸肽对 UV-B 的保护作用。共招募了 90 名年龄在 30-59 岁的健康男性和女性，并将他们随机分为两组，每组 45 人（半胱氨酸肽（48mg/天）和安慰剂）。在 5 周的测试食物摄入后，比较两组 UV-B 诱导的红斑和色素沉着的变化。与安慰剂组相比，半胱氨酸肽组的最小红斑剂量（MED）显著增加（p=0.019），表明抑制了 UV-B 诱导的红斑。与安慰剂组相比，半胱氨酸肽组的 ΔL值显著增加（***p<0.0001），表明色素沉着抑制。我们证明，口服半胱氨酸肽通过多种机制抑制 UV-B 诱导的红斑和色素沉着。因此，半胱氨酸肽可能作为维持皮肤健康和幸福感的营养保健品使用。UMIN 临床研究注册 ID：UMIN 000050157。
