Department of Pharmacognosy, Jingxian Hospital, No. 489, Taohuatan Road, Jingchuan Town, Jing County, Xuancheng City, 242500, Anhui Province, China.
BMC Cardiovasc Disord. 2024 Sep 27;24(1):517. doi: 10.1186/s12872-024-04190-6.
Heart failure in elderly individuals poses significant challenges due to the decline in cardiac function associated with aging. This study aimed to investigate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) for the treatment of heart failure, especially in elderly patients.
This was a retrospective case control study of the medical records of 60 elderly patients with heart failure admitted to our hospital between December 2020 and December 2023. Patients were divided into two groups based on treatment. The control group (n = 30) received diuretics, digitalis, and β receptor blockers, while the observation group (n = 30) received lyophilized rhBNP in addition to the control group treatment. Changes in BNP levels and clinical outcomes were compared between the two groups.
Posttreatment BNP levels were significantly lower in the observation group than in the control group (p < 0.05), and the total clinical effective rate was greater in the observation group (p < 0.05). Additionally, the left ventricular diameter, left atrial diameter, left ventricular shortening fraction, diastolic flow signal and cardiac output in the observation group were lower than those in the control group (p < 0.05), while the thickness of the aortic root diameter in the observation group was greater than that in the control group (p < 0.05).
RhBNP demonstrated ideal clinical efficacy in elderly patients with heart failure, improving symptoms and indicating potential for widespread use in the future.
老年人心力衰竭由于与衰老相关的心脏功能下降而带来重大挑战。本研究旨在探讨重组人脑利钠肽（rhBNP）治疗心力衰竭，尤其是老年患者的临床疗效。
这是一项回顾性病例对照研究，纳入了 2020 年 12 月至 2023 年 12 月期间我院收治的 60 例老年心力衰竭患者的病历资料。患者根据治疗方案分为两组。对照组（n=30）接受利尿剂、洋地黄和β受体阻滞剂治疗，观察组（n=30）在对照组治疗基础上加用冻干 rhBNP。比较两组患者 BNP 水平变化和临床结局。
观察组治疗后 BNP 水平明显低于对照组（p<0.05），观察组总临床有效率高于对照组（p<0.05）。此外，观察组左心室直径、左心房直径、左心室缩短分数、舒张期血流信号和心输出量均低于对照组（p<0.05），而观察组主动脉根部直径厚度大于对照组（p<0.05）。
rhBNP 对老年心力衰竭患者具有理想的临床疗效，改善了症状，表明其未来具有广泛应用的潜力。
