Department of Pediatric Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Department of Pediatric Pulmonology and Immunology, West China Women's and Children's Hospital: Sichuan University West China Second University Hospital, Sichuan Province, Chengdu, China.
Ital J Pediatr. 2024 Sep 27;50(1):195. doi: 10.1186/s13052-024-01768-w.
This study aims to report the phenomenon of Myelin oligodendrocyte glycoprotein antibody-associated encephalitis induced by Mycoplasma pneumoniae infections and promote the potential benefits of combining early immunotherapy and anti-M-pneumoniae therapy for these patients.
Three children with MOG-IgG-associated encephalitis due to M. pneumoniae infections who were treated at our hospital from September to November 2023 were included in the study. We investigated and analyzed the background and clinical features of these patients.
Three patients developed headaches, seizures, and/or other neurological manifestations, elevated mononuclear cells in cerebrospinal fluid, intracranial lesions on cranial magnetic resonance imaging (MRI), and positive MOG-IgG in serum, within 10-14 days. They were diagnosed with MOG-IgG-associated encephalitis due to M. pneumoniae infections, the treatment consisted of intravenous immunoglobulin, glucocorticoid, and erythromycin, then they were completely recovered.
Mycoplasma pneumoniae (M. pneumoniae) infections can cause oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis. The recognition of this condition will promote the potential benefits of combining early immunotherapy and anti-M. pneumoniae therapy for patients with MOG-IgG-associated encephalitis.
本研究旨在报告肺炎支原体感染诱导的髓鞘少突胶质细胞糖蛋白抗体相关脑炎现象，并探讨早期免疫治疗与抗肺炎支原体治疗联合应用于此类患者的潜在获益。
2023 年 9 月至 11 月，我院收治了 3 例肺炎支原体感染致髓鞘少突胶质细胞糖蛋白抗体相关脑炎患儿，对这些患者的背景和临床特征进行了调查和分析。
3 例患者均在感染后 10-14 天内出现头痛、癫痫发作和/或其他神经系统表现、脑脊液单核细胞增多、头颅磁共振成像（MRI）颅内病变、血清 MOG-IgG 阳性，被诊断为肺炎支原体感染致髓鞘少突胶质细胞糖蛋白抗体相关脑炎，治疗方案为静脉注射免疫球蛋白、糖皮质激素和红霉素，最终患者完全康复。
肺炎支原体（M. pneumoniae）感染可引起少突胶质细胞糖蛋白（MOG）抗体相关脑炎。对这种疾病的认识将促进早期免疫治疗与抗肺炎支原体治疗联合应用于 MOG-IgG 相关脑炎患者的潜在获益。
