Dewan Monia Vanessa, Weber Pia Deborah, Felderhoff-Mueser Ursula, Huening Britta Maria, Dathe Anne-Kathrin
Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.
Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University of Duisburg-Essen, 45122 Essen, Germany.
Children (Basel). 2024 Aug 30;11(9):1067. doi: 10.3390/children11091067.
BACKGROUND/OBJECTIVES: Very preterm infants are at increased risk of brain injury and impaired brain development. The Total Abnormality Score and biometric parameters, such as biparietal width, interhemispheric distance and transcerebellar diameter, are simple measures to evaluate brain injury, development and growth using cerebral magnetic resonance imaging data at term-equivalent age. The aim of this study was to evaluate the association between the Total Abnormality Score and biometric parameters with general movements in very preterm infants with brain injury.
This single-center retrospective cohort study included 70 very preterm infants (≤32 weeks' gestation and/or <1500 g birth weight) born between January 2017 and June 2021 in a level-three neonatal intensive care unit with brain injury-identified using cerebral magnetic resonance imaging data at term-equivalent age. General movements analysis was carried out at corrected age of 8-16 weeks. Binary logistic regression and Spearman correlation were used to examine the associations between the Total Abnormality Score and biometric parameters with general movements.
There was a significant association between the Total Abnormality Score and the absence of fidgety movements [OR: 1.19, 95% CI = 1.38-1.03] as well as a significant association between the transcerebellar diameter and fidgety movements (Spearman ρ = -0.269, < 0.05).
Among very preterm infants with brain injury, the Total Abnormality Score can be used to predict the absence of fidgety movements and may be an easily accessible tool for identifying high-risk very preterm infants and planning early interventions accordingly.
背景/目的：极早早产儿脑损伤及脑发育受损的风险增加。总异常评分以及双顶径、半球间距离和小脑横径等生物测量参数，是在足月等效年龄时使用脑磁共振成像数据评估脑损伤、发育和生长的简单指标。本研究的目的是评估脑损伤极早早产儿的总异常评分和生物测量参数与全身运动之间的关联。
这项单中心回顾性队列研究纳入了2017年1月至2021年6月期间在三级新生儿重症监护病房出生的70例极早早产儿（孕周≤32周和/或出生体重<1500g），这些患儿在足月等效年龄时通过脑磁共振成像数据被确定为脑损伤。在矫正年龄8至16周时进行全身运动分析。采用二元逻辑回归和Spearman相关性分析来检验总异常评分和生物测量参数与全身运动之间的关联。
总异常评分与无不安运动之间存在显著关联[比值比：1.19，95%置信区间=1.38 - 1.03]，并且小脑横径与不安运动之间也存在显著关联（Spearman相关系数ρ = -0.269，P<0.05）。
在脑损伤的极早早产儿中，总异常评分可用于预测无不安运动，可能是识别高危极早早产儿并据此制定早期干预措施的便捷工具。
