Gastroenterology and Digestive Endoscopy, Motility Unit, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Gastroenterology & Hepatology, Amsterdam University Medical Center, 1081 HV Amsterdam, The Netherlands.
Biomolecules. 2024 Aug 28;14(9):1080. doi: 10.3390/biom14091080.
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. EoE shares a common pathogenetic mechanism with other chronic disorders pertaining to the type 2 inflammatory spectrum, such as atopic dermatitis (AD), allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps (CRSwNP). The recent advancements in EoE pathogenesis understanding have unveiled new molecular targets implied within the "atopic march" picture as well as specific to EoE. These discoveries have led to the clinical evaluation of several novel drugs (monoclonal antibodies and immune modulators), specifically aimed at the modulation of Th2 inflammation. In this comprehensive review, we have focused on the subtle mechanisms of type 2 inflammatory disorders, highlighting the similarities and differences with EoE, taking a deeper look into the evolving field of biologic therapies, already approved or under current investigation.
嗜酸性食管炎（EoE）是一种慢性食管炎症性疾病。EoE 与其他与 2 型炎症谱相关的慢性疾病（如特应性皮炎、过敏性鼻炎、哮喘和伴有鼻息肉的慢性鼻-鼻窦炎）具有共同的发病机制。近年来，EoE 发病机制的研究进展揭示了“特应性进行曲”中以及特定于 EoE 的新的分子靶点。这些发现导致了几种新型药物（单克隆抗体和免疫调节剂）的临床评估，这些药物专门针对调节 Th2 炎症。在这篇全面的综述中，我们专注于 2 型炎症性疾病的微妙机制，强调其与 EoE 的相似性和不同之处，并深入探讨已批准或正在研究中的生物治疗的不断发展的领域。
