氧化应激与血糖控制良好和不佳的 2 型糖尿病患者的天门冬氨酸水平。

Oxidative Stress and Asprosin Levels in Type 2 Diabetic Patients with Good and Poor Glycemic Control.

机构信息

Department of Internal Medicine, Faculty of Medicine, Istanbul Atlas University, Istanbul 34408, Türkiye.

Department of Medical Biochemistry, Faculty of Medicine, Izmir Katip Celebi University, Izmir 35620, Türkiye.

出版信息

Biomolecules. 2024 Sep 5;14(9):1123. doi: 10.3390/biom14091123.

DOI:10.3390/biom14091123

PMID:39334889

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430680/

Abstract

HbA1c is the most widely used test as an indicator of glucoregulation in patients with type 2 diabetes mellitus (T2DM). Asprosin and oxidative stress levels can be reduced with good glycemic control (GC) and thus prevented or delayed micro/macro complications in patients with T2DM. The relationship between asprosin, which is thought to affect GC, and oxidative stress parameters such as lipid hydroperoxides (LOOHs), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (Cu,Zn-SOD), and total antioxidant capacity (TAC) was evaluated in T2DM patients. The study was conducted prospectively in 75 healthy people admitted to the hospital for a general health check-up and 150 T2DM patients treated in the diabetes outpatient clinic. The patient's glycemic status measurements were categorized as good glycemic control group (GGC) is defined as HbA1c < 7 and poor glycemic control (PGC) group is defined as HbA1c ≥ 7. The study found a consistent increase in LOOH and MDA levels across the control, GGC, and PGC groups, while GSH, Cu/Zn-SOD, and TAC levels decreased in these respective groups. Additionally, asprosin levels showed a gradual rise in all groups. Positive correlations were observed between asprosin levels and various metabolic and oxidative stress markers, including BMI, WC, FBG, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), DM duration, LOOH, and MDA, while negative correlations were noted with GSH, Cu/Zn-SOD, and TAC specifically in the PGC group. Furthermore, multivariate regression analysis identified HOMA-IR as the primary influencing factor on asprosin levels in PGC patients. Current glycemic dysregulation may lead to increased circulating asprosin and oxidative stress, which cause complications. Since asprosin levels may be an important hormonal factor in determining GC in T2DM, the use of this hormone may be recommended in the future to accelerate therapeutic approaches in T2DM. Early diagnosis and appropriate treatment may delay the development and progression of diabetic complications.

摘要

糖化血红蛋白（HbA1c）是 2 型糖尿病（T2DM）患者血糖调节的最常用指标。通过良好的血糖控制（GC）可以降低天冬氨酸蛋白和氧化应激水平，从而预防或延缓 T2DM 患者的微/宏观并发症。本研究旨在评估 T2DM 患者中天冬氨酸蛋白（被认为影响 GC）与脂质过氧化物（LOOHs）、谷胱甘肽（GSH）、丙二醛（MDA）、超氧化物歧化酶（Cu，Zn-SOD）和总抗氧化能力（TAC）等氧化应激参数之间的关系。本研究前瞻性纳入 75 名因常规健康检查而入院的健康人和 150 名在糖尿病门诊治疗的 T2DM 患者。根据患者的血糖状态测量结果，将其分为良好血糖控制组（GGC），定义为 HbA1c＜7；和不良血糖控制组（PGC），定义为 HbA1c≥7。研究发现，随着对照组、GGC 和 PGC 组的 LOOH 和 MDA 水平逐渐升高，GSH、Cu/Zn-SOD 和 TAC 水平逐渐降低。此外，天冬氨酸蛋白水平在所有组中均呈逐渐升高趋势。天冬氨酸蛋白水平与各种代谢和氧化应激标志物呈正相关，包括 BMI、WC、FBG、胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、DM 病程、LOOH 和 MDA；而与 GSH、Cu/Zn-SOD 和 TAC 呈负相关，仅在 PGC 组中具有统计学意义。此外，多元回归分析发现，HOMA-IR 是 PGC 患者中天冬氨酸蛋白水平的主要影响因素。目前的血糖失调可能导致循环中天冬氨酸蛋白和氧化应激的增加，从而导致并发症。由于天冬氨酸蛋白水平可能是决定 T2DM 患者 GC 的重要激素因素，因此未来可能推荐使用该激素来加速 T2DM 的治疗方法。早期诊断和适当治疗可能会延迟糖尿病并发症的发生和发展。