Coombs Reilly A, Jebastin Thangaiah Judith, Siontis Brittany L, Robinson Steven I, Okuno Scott H, Houdek Matthew T, Xu-Welliver Meng, Ho Thanh P
School of Medicine, Medical College of Wisconsin-Central Wisconsin, Wausau, WI 54401, USA.
Department of Research and Innovation, Mayo Clinic Health System, Rochester, MN 55905, USA.
Cancers (Basel). 2024 Sep 23;16(18):3233. doi: 10.3390/cancers16183233.
Myxoid liposarcoma predominantly affects young and middle-aged individuals, and little is known regarding treatment tolerability and outcomes in older patients. This study aims to better understand this older patient population.
This single institution retrospective study included patients aged 70 years and older with localized (non-metastatic) myxoid liposarcoma.
Sixteen patients were included. The median age was 75 years, and 9 (56%) were female. Fourteen (88%) were extremity tumors and two (12%) were trunk. The median tumor size was 10.4 cm (range, 3.6 to 28 cm). Five (31%) tumors had a round cell component. All patients had surgery. Fourteen (88%) had perioperative radiation, and three (19%) had perioperative chemotherapy. One patient had postoperative infection, and one patient had neutropenic fever from preoperative chemotherapy. The median follow up from surgery was 6.3 years. Eight (50%) patients died from MLPS. The median relapse-free survival and overall survival were 34 months and 75 months, respectively.
Most older patients with localized MLPS received perioperative radiation therapy with surgery, and few serious toxicities were reported. Even with treatment, half of the patients relapsed.
黏液样脂肪肉瘤主要影响中青年个体，关于老年患者的治疗耐受性和治疗结果知之甚少。本研究旨在更好地了解这一老年患者群体。
这项单机构回顾性研究纳入了70岁及以上患有局限性（非转移性）黏液样脂肪肉瘤的患者。
共纳入16例患者。中位年龄为75岁，9例（56%）为女性。14例（88%）为肢体肿瘤，2例（12%）为躯干肿瘤。中位肿瘤大小为10.4 cm（范围3.6至28 cm）。5例（31%）肿瘤有圆形细胞成分。所有患者均接受了手术。14例（88%）接受了围手术期放疗，3例（19%）接受了围手术期化疗。1例患者发生术后感染，1例患者因术前化疗出现中性粒细胞减少性发热。术后中位随访时间为6.3年。8例（50%）患者死于黏液样脂肪肉瘤。无复发生存期和总生存期的中位数分别为34个月和75个月。
大多数患有局限性黏液样脂肪肉瘤的老年患者在手术的同时接受了围手术期放疗，且报告的严重毒性反应较少。即使接受了治疗，仍有一半的患者复发。
