Rhim Haerin, Godke Ashleigh M, Aguilar M Graciela, Mitchell Mark A
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Animals (Basel). 2024 Sep 11;14(18):2636. doi: 10.3390/ani14182636.
Common blue-tongued skinks () are popular pet reptiles; however, there has been limited research to investigate sedatives for this species. The purpose of this study was to measure the physiologic effects of four combinations of alfaxalone, dexmedetomidine, and midazolam for minor procedures such as intubation and blood collection. Eleven common blue-tongued skinks () were used for this prospective, randomized cross-over study. The subcutaneous combinations were used as follows: 20 mg/kg alfaxalone (A); 10 mg/kg alfaxalone and 1 mg/kg midazolam (AM); 0.1 mg/kg dexmedetomidine and 1 mg/kg midazolam (DM); and 5 mg/kg alfaxalone, 0.05 mg/kg dexmedetomidine, and 0.5 mg/kg midazolam (ADM). Heart rate, respiratory rate, palpebral reflex, righting reflex, escape reflex, toe pinch withdrawal reflex, tongue flicking, and the possibility of intubation were recorded at baseline and every 5 min for 60 min. Venous blood gases were measured at baseline, full sedation, and recovery. Heart and respiratory rates decreased significantly in all groups, but the reductions were most prominent in DM and ADM. Analgesic effects, as measured by the toe pinch withdrawal reflex, were only observed in DM and ADM. Intubation was possible in all four protocols; however, it was not possible in two DM skinks. Based on these trials, ADM and AM are recommended for minor procedures in blue-tongue skinks.
普通蓝舌石龙子是受欢迎的宠物爬行动物；然而，针对该物种的镇静剂研究有限。本研究的目的是测量阿法沙龙、右美托咪定和咪达唑仑四种组合用于插管和采血等小手术时的生理效应。11只普通蓝舌石龙子用于这项前瞻性、随机交叉研究。皮下用药组合如下：20mg/kg阿法沙龙（A）；10mg/kg阿法沙龙和1mg/kg咪达唑仑（AM）；0.1mg/kg右美托咪定和1mg/kg咪达唑仑（DM）；以及5mg/kg阿法沙龙、0.05mg/kg右美托咪定和0.5mg/kg咪达唑仑（ADM）。在基线时以及之后60分钟内每5分钟记录心率、呼吸频率、眼睑反射、翻正反射、逃避反射、趾捏退缩反射、吐舌情况以及插管可能性。在基线、完全镇静和恢复时测量静脉血气。所有组的心率和呼吸频率均显著下降，但DM组和ADM组下降最为明显。通过趾捏退缩反射测量的镇痛效果仅在DM组和ADM组中观察到。所有四种方案均可行插管；然而，两只DM组石龙子无法插管。基于这些试验，推荐ADM和AM用于蓝舌石龙子的小手术。
