Davis M M
Annu Rev Immunol. 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541.
Characterization of cDNA and genomic clones encoding the Beta chain of the T-cell receptor for antigen reveals a very close resemblance to immunoglobulin: V, D, J, and C elements; the mechanism of rearrangement; and the potential extent of diversity, explaining the relatively large T-cell repertoire of specificities and the clonal nature of individual responses. Differences with immunoglobulins are evident in the much more heterogeneous V beta sequences, which appear to have additional hypervariable regions. Together these data predict a roughly immunoglobulin-like structure for the receptor, but with potentially significant variation from immunoglobulin in the nature of the combining site(s).
编码抗原特异性T细胞受体β链的cDNA和基因组克隆的特征显示，其与免疫球蛋白极为相似：具有V、D、J和C元件；重排机制；以及潜在的多样性程度，这解释了相对庞大的T细胞特异性库和个体反应的克隆性质。与免疫球蛋白的差异在更为异质的Vβ序列中很明显，这些序列似乎有额外的高变区。这些数据共同预测该受体具有大致类似免疫球蛋白的结构，但结合位点的性质可能与免疫球蛋白有显著差异。
