Lo Buono Viviana, Corallo Francesco, Sessa Edoardo, D'Aleo Giangaetano, Rifici Carmela, Quartarone Angelo, Bonanno Lilla
IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Brain Sci. 2024 Aug 28;14(9):866. doi: 10.3390/brainsci14090866.
Multiple sclerosis (MS) is a chronic and progressive neurological disease that affects the central nervous system, resulting in a wide spectrum of cognitive, emotional, and physical deficits. The progressive course of MS poses significant challenges to patients and has a profound impact on health-related quality of life (HRQoL). The style of coping adopted plays a critical role in determining how individuals with MS adapt to and face the challenges of the disease and their overall well-being. This paper aims to examine the impact of coping strategies on HRQoL in young adults un-/minimally impaired (<5 years, EDSS ≤ 2.5) by MS (age 18-35 years). This retrospective cross-sectional cohort study included 98 young adults (33 males and 65 females) with relapsing-remitting MS who underwent neurological assessment using the Expanded Disability Status Scale. Participants completed the Italian version of the Multiple Sclerosis QoL-54 (MSQoL-54), which provides a physical and mental health score, and the Coping Orientation to Problems Experienced Inventory (Brief-COPE). The results showed a significant relationship between COPE scores and physical and mental health. Subjects affected by MS who tend to use more frequent coping strategies such as active planning, personal growth, and acceptance showed a better overall well-being and quality of life. These findings are relevant to clinical practice given the need to understand the coping variable to improve HRQoL. Understanding these relationships is crucial for developing effective interventions to enhance the well-being of MS subjects.
多发性硬化症（MS）是一种慢性进行性神经疾病，会影响中枢神经系统，导致一系列认知、情感和身体方面的缺陷。MS的进展过程给患者带来了重大挑战，并对健康相关生活质量（HRQoL）产生深远影响。所采用的应对方式在决定MS患者如何适应和面对疾病挑战及其整体幸福感方面起着关键作用。本文旨在研究应对策略对MS（年龄18 - 35岁）导致的未受损/轻度受损（<5年，扩展残疾状态量表[EDSS]≤2.5）的年轻成年人HRQoL的影响。这项回顾性横断面队列研究纳入了98名复发缓解型MS的年轻成年人（33名男性和65名女性），他们使用扩展残疾状态量表进行了神经学评估。参与者完成了意大利语版的多发性硬化症生活质量量表54（MSQoL - 54），该量表提供了身心健康得分，以及经历问题应对取向量表（简易应对方式问卷[Brief - COPE]）。结果显示应对方式得分与身心健康之间存在显著关系。倾向于使用更频繁应对策略（如积极规划、个人成长和接受）的MS患者总体幸福感和生活质量更好。鉴于需要了解应对变量以改善HRQoL，这些发现与临床实践相关。理解这些关系对于制定有效的干预措施以提高MS患者的幸福感至关重要。
