Lim Jong Hyun, Kim Myung Ji
Department of Neurosurgery, Korea University Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan 15355, Gyeonggi-do, Republic of Korea.
Biomedicines. 2024 Sep 3;12(9):2003. doi: 10.3390/biomedicines12092003.
Stereotactic radiosurgery (SRS) is an effective treatment strategy for cerebral arteriovenous malformations (AVMs). Aggressive treatment achieving complete obliteration is necessary to prevent further intracranial hemorrhage and neurological deficits. However, SRS treatment of large AVMs (>10 cm) is challenging. To prevent toxicity in the normal brain tissue, it is imperative to reduce the radiation dose as the lesion volume increases; however, this also reduces the rate of obliteration. In this study, we review the various radiosurgical approaches for treating large AVMs and their outcomes, and suggest ways to improve treatment outcomes during SRS for large AVMs.
立体定向放射外科手术（SRS）是治疗脑动静脉畸形（AVM）的一种有效治疗策略。为预防进一步的颅内出血和神经功能缺损，采取积极治疗实现完全闭塞是必要的。然而，SRS治疗大型AVM（>10 cm）具有挑战性。为防止正常脑组织出现毒性，随着病变体积增大，必须降低辐射剂量；然而，这也会降低闭塞率。在本研究中，我们回顾了治疗大型AVM的各种放射外科方法及其结果，并提出了在大型AVM的SRS治疗期间改善治疗结果的方法。
