Shen Danting, Li Cong, Liu Shuhua, Lin Anping, Liu Bin
Department of Gynecology, Shenzhen Baoan Women's and Children's Hospital, 56 Yulv Road, Shenzhen 510181, China.
Maternal & Child Health Research Institute, Shenzhen Baoan Women's and Children's Hospital, 56 Yulv Road, Shenzhen 510181, China.
Biomedicines. 2024 Sep 9;12(9):2044. doi: 10.3390/biomedicines12092044.
: Intrauterine adhesion (IUA) is characterized by endometrial fibrocyte hyperplasia. The gene is associated with many proliferative diseases. However, its association with IUA is entirely unknown. We hypothesized that gene polymorphisms are responsible for IUA susceptibility after curettage abortion. : In this genetic association study, We genotyped two common polymorphisms (rs369065 C>T and rs314280 A>G) in 107 patients with IUA and 270 controls without IUA after curettage abortion from a Chinese population between July 2022 and May 2023 and analyzed their associations with IUA risk using multiple logistic regression models. : The carriers of genotype rs314280 AA of the gene showed an increased risk of IUA (AOR [adjusted odds ratio] = 2.12, 95% CI [confidence interval] = 1.151-3.903), compared to GG+GA genotypes. Further stratification analyses showed that the deleterious role of the rs314280 AA genotype was more evident in patients with fewer than four pregnancies (AOR = 2.740, 95% CI = 1.355-5.540), fewer than two births (AOR = 2.676, 95% CI = 1.300-5.509), and fibrous (AOR = 2.082, 95% CI = 1.084-3.997) and muscular adhesions (AOR = 3.887, 95% CI = 1.116-13.540). However, the rs369065 T>C polymorphism of the gene was not significantly associated with the occurrence of IUA. : The rs314280 AA genotype of the gene is associated with an increased risk of IUA in patients after curettage abortion, especially in those with fewer pregnancies or parities and higher disease severity. Our findings implicate a precise choice of clinical counseling and decision-making of IUA, thereby protecting female reproduction.
宫腔粘连（IUA）的特征是子宫内膜纤维细胞增生。该基因与许多增殖性疾病有关。然而，其与IUA的关联尚完全未知。我们推测该基因多态性是刮宫流产后IUA易感性的原因。：在这项基因关联研究中，我们对2022年7月至2023年5月期间来自中国人群的107例IUA患者和270例刮宫流产后无IUA的对照者进行了两种常见多态性（rs369065 C>T和rs314280 A>G）的基因分型，并使用多元逻辑回归模型分析了它们与IUA风险的关联。：与GG+GA基因型相比，该基因rs314280 AA基因型携带者的IUA风险增加（调整优势比[AOR]=2.12，95%置信区间[CI]=1.151-3.903）。进一步的分层分析表明，rs314280 AA基因型的有害作用在妊娠少于4次（AOR=2.740，95%CI=1.355-5.540）、分娩少于2次（AOR=2.676，95%CI=1.300-5.509）以及纤维性（AOR=2.082，95%CI=1.084-3.997）和肌肉粘连（AOR=3.887，95%CI=1.116-13.540）的患者中更为明显。然而，该基因的rs369065 T>C多态性与IUA的发生无显著关联。：该基因的rs314280 AA基因型与刮宫流产后患者的IUA风险增加有关，尤其是在妊娠或产次较少以及疾病严重程度较高的患者中。我们的研究结果表明在IUA的临床咨询和决策中要进行精确选择，从而保护女性生殖功能。
