Tseilikman Vadim E, Tseilikman Olga B, Shevyrin Vadim A, Yegorov Oleg N, Epitashvili Alexandr A, Aristov Maxim R, Karpenko Marina N, Lipatov Ilya A, Pashkov Anton A, Shamshurin Maxim V, Buksha Irina A, Shonina Anna K, Kolesnikova Alexandra, Shatilov Vladislav A, Zhukov Maxim S, Novak Jurica
Scientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
Zelman Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.
Biomedicines. 2024 Sep 10;12(9):2063. doi: 10.3390/biomedicines12092063.
Stress-related anxiety disorders and anxiety-like behavior in post-traumatic stress disorder (PTSD) are associated with altered neurocircuitry pathways, neurotransmitter systems, and the activities of monoamine and glucocorticoid-metabolizing enzymes. Resveratrol, a natural polyphenol, is recognized for its antioxidant, anti-inflammatory, and antipsychiatric properties. Previous studies suggest that resveratrol reduces anxiety-like behavior in animal PTSD models by downregulating key enzymes such as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and monoamine oxidases (MAOs). However, the underlying mechanisms remain unclear. In this study, we explored the efficacy of resveratrol in treating stress-induced anxiety using a chronic predator stress model in rats. Resveratrol was administered intraperitoneally at 100 mg/kg following a 10-day stress exposure, and anxiety behavior was assessed with an elevated plus maze. Our results indicated that stress-related anxiety correlated with increased activities of brain MAO-A, MAO-B, and hepatic 11β-HSD-1, alongside elevated oxidative stress markers in the brain and liver. Resveratrol treatment improved anxiety behavior and decreased enzyme activities, oxidative stress, and hepatic damage. We demonstrate that resveratrol exerts antianxiogenic effects by modulating glucocorticoid and monoamine metabolism in the brain and liver. These findings suggest resveratrol's potential as a therapeutic agent for anxiety disorders, warranting further clinical investigation.
创伤后应激障碍（PTSD）中与应激相关的焦虑症和焦虑样行为与神经回路通路、神经递质系统以及单胺和糖皮质激素代谢酶的活性改变有关。白藜芦醇是一种天然多酚，因其抗氧化、抗炎和抗精神病特性而闻名。先前的研究表明，白藜芦醇通过下调关键酶，如1型11β-羟基类固醇脱氢酶（11β-HSD-1）和单胺氧化酶（MAO），来减少动物PTSD模型中的焦虑样行为。然而，其潜在机制仍不清楚。在本研究中，我们使用大鼠慢性捕食者应激模型探索了白藜芦醇治疗应激诱导焦虑的疗效。在10天的应激暴露后，以100mg/kg的剂量腹腔注射白藜芦醇，并用高架十字迷宫评估焦虑行为。我们的结果表明，与应激相关的焦虑与脑MAO-A、MAO-B和肝脏11β-HSD-1的活性增加相关，同时脑和肝脏中的氧化应激标志物升高。白藜芦醇治疗改善了焦虑行为，降低了酶活性、氧化应激和肝脏损伤。我们证明，白藜芦醇通过调节脑和肝脏中的糖皮质激素和单胺代谢发挥抗焦虑作用。这些发现表明白藜芦醇作为焦虑症治疗药物的潜力，值得进一步的临床研究。
