Scientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia.
Int J Mol Sci. 2023 Sep 20;24(18):14343. doi: 10.3390/ijms241814343.
Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing and Freezing phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.
目前，创伤后应激障碍（PTSD）的药物治疗效果不尽人意，这使得营养支持成为一种有前途的治疗方法。最近的研究已经确定了白藜芦醇对 PTSD 的保护作用。在这里，我们测试了奶酪消费与白藜芦醇补充剂联合用于 PTSD 实验模型的行为和神经生物学效应。使用高架十字迷宫测试，我们观察到奶酪摄入导致焦虑样行为向抑郁样行为转变，表现为冻结行为增加。然而，焦虑指数值没有观察到显著变化。有趣的是，奶酪和白藜芦醇的补充仅导致一半 PTSD 大鼠的冻结行为消除。我们根据冻结行为将大鼠进一步分为两组：冻结和非冻结表型。白藜芦醇改善了海马中单胺氧化酶-A 和脑源性神经营养因子基因表达的异常，但仅在冻结大鼠中。此外，还发现冻结行为的次数与海马中单胺氧化酶-A 和脑源性神经营养因子 mRNA 的水平之间存在负相关。该研究结果表明，白藜芦醇补充治疗 PTSD 有希望。需要进一步的研究来更好地理解潜在的机制，并优化白藜芦醇补充治疗 PTSD 的潜在益处。
