Chardalias Leonidas, Skreka Androniki-Maria, Memos Nikolaos, Nieri Alexandra-Stavroula, Politis Dimitrios, Politou Marianna, Theodosopoulos Theodosios, Papaconstantinou Ioannis
2nd Surgical Department, Aretaieion University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Department of Nursing, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Biomedicines. 2024 Sep 13;12(9):2094. doi: 10.3390/biomedicines12092094.
Anemia is the most common extraintestinal symptom of colorectal cancer, with a prevalence of 30-75%. While the preoperative anemia in this patient population has been well studied and its correction 4-6 weeks prior to surgery is recommended when feasible, there is a paucity of data regarding the management of postoperative anemia, which has a prevalence of up to 87% in these patients. To address this issue, we conducted an observational cohort study of surgically treated postoperative anemic patients with colorectal cancer. The objective of this study was to evaluate the effect of intravenous ferric carboxymaltose on the correction of postoperative anemia by postoperative day 30 (POD30). The primary outcome was the change in hemoglobin on POD30, while the secondary outcomes were the change in iron and other laboratory parameters, postoperative complications and transfusions. The results demonstrated that patients treated with intravenous iron exhibited a significant increase in hemoglobin levels by POD30, along with a concomitant increase in hematocrit, ferritin, and transferrin saturation levels, compared to the control group. The findings imply that patients undergoing colorectal cancer surgery with anemia that was not corrected in the preoperative setting may benefit from early postoperative intravenous iron infusion.
贫血是结直肠癌最常见的肠外症状，患病率为30%-75%。虽然对该患者群体术前贫血情况已有充分研究，且建议在可行时于手术前4-6周纠正贫血，但关于术后贫血管理的数据却很匮乏，这类患者术后贫血患病率高达87%。为解决这一问题，我们对接受手术治疗的结直肠癌术后贫血患者进行了一项观察性队列研究。本研究的目的是评估静脉注射羧基麦芽糖铁对术后30天（POD30）纠正术后贫血的效果。主要结局是POD30时血红蛋白的变化，次要结局是铁及其他实验室参数的变化、术后并发症和输血情况。结果表明，与对照组相比，接受静脉补铁治疗的患者到POD30时血红蛋白水平显著升高，同时血细胞比容、铁蛋白和转铁蛋白饱和度水平也随之升高。研究结果表明，术前未纠正贫血的结直肠癌手术患者可能从术后早期静脉补铁中获益。
