Wasuwanich Paul, Karnsakul Wikrom
Department of Internal Medicine, Naples Comprehensive Health, Naples, FL 34102, USA.
Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Diagnostics (Basel). 2024 Sep 10;14(18):1999. doi: 10.3390/diagnostics14181999.
As life expectancy in cystic fibrosis (CF) patients has increased, so has the incidence of cancers. We aimed to investigate and describe gastrointestinal cancers in CF hospitalized patients from 2010 to 2020.
Utilizing the National Inpatient Sample, we extracted cases of CF-associated hospitalizations and gastrointestinal cancers as well as demographic and clinical data. We compared our CF cohort to age, sex, and race/ethnicity-matched controls. Trends were analyzed by Poisson regression.
We identified a total of 902 hospitalizations of CF with gastrointestinal cancer; among them, 539 (59.8%) were colorectal, 139 (15.4%) were liver, 105 (11.6%) were pancreatic, 54 (6.0%) were small bowel, 35 (3.9%) were gastric, and 30 (3.3%) were esophageal cancers. The median age of hospitalization for gastrointestinal cancers ranged from 39 years in liver cancer to 65 years in small bowel cancer. Mortality ranged from 9.5% in pancreatic to 0.0% in small bowel cancer. Colorectal cancer (IRR: 1.09; = 0.005), pancreatic cancer (IRR: 1.17; = 0.023), gastric cancer (IRR: 1.41; = 0.003), and esophageal cancer (IRR: 1.50; = 0.023) hospitalization rates have been increasing over time. Rates of colorectal ( = 0.037) cancer were significantly higher in our CF cohort compared to controls.
Colorectal cancers are the major gastrointestinal cancers in CF patients, and the incidence of these hospitalizations is increasing.
随着囊性纤维化（CF）患者预期寿命的延长，癌症发病率也有所上升。我们旨在调查和描述2010年至2020年期间CF住院患者的胃肠道癌症情况。
利用国家住院样本，我们提取了CF相关住院病例、胃肠道癌症病例以及人口统计学和临床数据。我们将CF队列与年龄、性别和种族/族裔匹配的对照组进行了比较。通过泊松回归分析趋势。
我们共确定了902例CF合并胃肠道癌症的住院病例；其中，539例（59.8%）为结直肠癌，139例（15.4%）为肝癌，105例（11.6%）为胰腺癌，54例（6.0%）为小肠癌，35例（3.9%）为胃癌，30例（3.3%）为食管癌。胃肠道癌症住院的中位年龄从肝癌的39岁到小肠癌的65岁不等。死亡率从胰腺癌的9.5%到小肠癌的0.0%不等。结直肠癌（发病率比：1.09；P = 0.005）、胰腺癌（发病率比：1.17；P = 0.023）、胃癌（发病率比：1.41；P = 0.003）和食管癌（发病率比：1.50；P = 0.023）的住院率随时间呈上升趋势。与对照组相比，我们的CF队列中结直肠癌（P = 0.037）的发病率显著更高。
结直肠癌是CF患者主要的胃肠道癌症，且这些住院病例的发病率正在上升。
