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巨细胞动脉炎:简单的超声检查能否预防复杂后果?

Giant Cell Arteritis: Can Simple Ultrasound Examination Prevent Complex Consequences?

作者信息

Stańska Wiktoria, Kruszewski Robert, Juszkiewicz Aleksandra, Bachta Artur, Tłustochowicz Witold

机构信息

Department of Internal Medicine and Rheumatology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.

出版信息

Diagnostics (Basel). 2024 Sep 19;14(18):2071. doi: 10.3390/diagnostics14182071.

DOI:10.3390/diagnostics14182071
PMID:39335750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11431179/
Abstract

Giant cell arteritis (GCA) is a rare disease of the arteries, occurring mainly in the elderly. Although the involvement of temporal arteries can be mostly symptomatic, the occlusion of ophthalmic arteries has severe consequences. GCA affecting temporal arteries is an emergency requiring quick commencement of treatment with glucocorticoids due to the serious consequences of neglect-blindness. According to the new guidelines released by EULAR, ultrasound is the tool of choice in support of the clinical diagnosis of giant cell arteritis, replacing temporal artery biopsy (TAB), as it is a sensitive and non-invasive method that is widely available. The main limitation is that the reliability of this imaging is based on the technical expertise of ultrasonographers. However, performing imaging should not delay commencing the treatment. In this work, we present ultrasound images from a case report of a 74-year-old female patient where difficulties in establishing a diagnosis led to vision loss in both eyes. In this example, we describe the ultrasound findings in giant cell arteritis, emphasizing its usefulness in supporting a diagnosis of GCA.

摘要

巨细胞动脉炎(GCA)是一种罕见的动脉疾病,主要发生于老年人。虽然颞动脉受累大多有症状,但眼动脉闭塞会产生严重后果。由于忽视失明的严重后果,累及颞动脉的GCA是一种需要迅速开始使用糖皮质激素治疗的急症。根据欧洲抗风湿病联盟(EULAR)发布的新指南,超声是支持巨细胞动脉炎临床诊断的首选工具,取代了颞动脉活检(TAB),因为它是一种敏感且非侵入性的方法,广泛可用。主要局限性在于这种成像的可靠性取决于超声检查人员的技术专长。然而,进行成像不应延迟开始治疗。在这项工作中,我们展示了一名74岁女性患者病例报告的超声图像,该患者在诊断过程中遇到困难,导致双眼视力丧失。在这个例子中,我们描述了巨细胞动脉炎的超声表现,强调其在支持GCA诊断方面的有用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dc7/11431179/86daee628e84/diagnostics-14-02071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dc7/11431179/0b92e439ba2a/diagnostics-14-02071-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dc7/11431179/86daee628e84/diagnostics-14-02071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dc7/11431179/0b92e439ba2a/diagnostics-14-02071-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dc7/11431179/86daee628e84/diagnostics-14-02071-g002.jpg

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本文引用的文献

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Visual manifestations in giant cell arteritis: identification of risk factors from the ARTESER Registry.巨细胞动脉炎的视觉表现:来自ARTESER注册研究的危险因素识别
Rheumatology (Oxford). 2025 Feb 1;64(2):697-703. doi: 10.1093/rheumatology/keae042.
2
Executive summary on the optimization of the multidisciplinary and integrated approach to polymyalgia rheumatica and giant cell arteritis in Madrid region.马德里地区关于优化巨细胞动脉炎和多发性肌炎的多学科综合治疗方法的执行摘要。
Rev Clin Esp (Barc). 2024 Jan;224(1):48-56. doi: 10.1016/j.rceng.2023.12.009. Epub 2023 Dec 22.
3
EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update.
EULAR 临床实践中应用影像学诊断大血管血管炎的推荐:2023 年更新版。
Ann Rheum Dis. 2024 May 15;83(6):741-751. doi: 10.1136/ard-2023-224543.
4
Long delay from symptom onset to first consultation contributes to permanent vision loss in patients with giant cell arteritis: a cohort study.症状发作到首次就诊的时间间隔较长可导致巨细胞动脉炎患者永久性视力丧失:一项队列研究。
RMD Open. 2023 Jan;9(1). doi: 10.1136/rmdopen-2022-002866.
5
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.2021 年美国风湿病学会/脉管炎基金会巨细胞动脉炎和 Takayasu 动脉炎管理指南。
Arthritis Rheumatol. 2021 Aug;73(8):1349-1365. doi: 10.1002/art.41774. Epub 2021 Jul 8.
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Diagnosis of giant cell arteritis.巨细胞动脉炎的诊断。
Rheumatology (Oxford). 2020 May 1;59(Suppl 3):iii5-iii16. doi: 10.1093/rheumatology/kez553.
7
2018 Update of the EULAR recommendations for the management of large vessel vasculitis.2018 年版 EULAR 大血管血管炎管理建议更新。
Ann Rheum Dis. 2020 Jan;79(1):19-30. doi: 10.1136/annrheumdis-2019-215672. Epub 2019 Jul 3.
8
OMERACT Definitions for Ultrasonographic Pathologies and Elementary Lesions of Rheumatic Disorders 15 Years On.OMERACT 类风湿性疾病超声病理和基本损害定义 15 年回顾。
J Rheumatol. 2019 Oct;46(10):1388-1393. doi: 10.3899/jrheum.181095. Epub 2019 Feb 1.
9
Evaluating the Incidence of Arteritic Ischemic Optic Neuropathy and Other Causes of Vision Loss from Giant Cell Arteritis.评估动脉炎性缺血性视神经病变的发病率以及巨细胞动脉炎导致视力丧失的其他原因。
Ophthalmology. 2016 Sep;123(9):1999-2003. doi: 10.1016/j.ophtha.2016.05.008. Epub 2016 Jun 11.