Cristescu Liviu, Tilea Ioan, Iancu Dragos-Gabriel, Stoica Florin, Moldovan Diana-Andreea, Capriglione Vincenzo, Varga Andreea
Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Diagnostics (Basel). 2024 Sep 23;14(18):2102. doi: 10.3390/diagnostics14182102.
Chronic heart failure (CHF) is characterized by complex pathophysiology, leading to increased hospitalizations and mortality. Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) provide valuable diagnostic insights.
This study evaluates the prognostic relationship between NLR, PLR, and, in a specific subcohort, N-terminal pro B-type natriuretic peptide (NT-proBNP), alongside length of stay (LOS) and 90-day readmission rates in CHF patients, irrespective of heart failure phenotype. A retrospective analysis of 427 CHF admissions (males = 57.84%) was conducted.
The mean age of the entire population was 68.48 ± 11.53 years. The average LOS was 8.33 ± 5.26 days, with a readmission rate of 73 visits (17.09%) for 56 patients. The NLR (3.79 ± 3.32) showed a low but positive correlation with the LOS (r = 0.222, < 0.001). Conversely, the PLR (144.84 ± 83.08) did not demonstrate a significant association with the LOS. The NLR presented a low negative correlation for days until the next admission (r = -0.023, = 0.048). In a prespecified subanalysis of 323 admissions, the NT-proBNP exhibited a low positive Pearson correlation with the NLR (r = 0.241, < 0.001) and PLR (r = 0.151, = 0.006).
The impact of the NLR across heart failure phenotypes may suggest the role of systemic inflammation in understanding and managing CHF.
慢性心力衰竭（CHF）具有复杂的病理生理学特征，导致住院率和死亡率增加。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）等炎症生物标志物提供了有价值的诊断见解。
本研究评估了NLR、PLR以及在特定亚组中N末端B型利钠肽原（NT-proBNP）与CHF患者住院时间（LOS）和90天再入院率之间的预后关系，而不考虑心力衰竭表型。对427例CHF住院患者（男性占57.84%）进行了回顾性分析。
整个人口的平均年龄为68.48±11.53岁。平均住院时间为8.33±5.26天，56例患者的再入院率为73次（17.09%）。NLR（3.79±3.32）与住院时间呈低但正相关（r = 0.222，<0.001）。相反，PLR（144.84±83.08）与住院时间未显示出显著关联。NLR与下次入院前天数呈低负相关（r = -0.023，= 0.048）。在对323例住院患者的预先指定亚分析中，NT-proBNP与NLR（r = 0.241，<0.001）和PLR（r = 0.151，= 0.006）呈低正Pearson相关性。
NLR对心力衰竭各表型的影响可能提示全身炎症在理解和管理CHF中的作用。
