Department of Pediatrics, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia.
Department of Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia.
Medicina (Kaunas). 2024 Aug 26;60(9):1394. doi: 10.3390/medicina60091394.
: Cerebral palsy (CP) significantly impacts quality of life globally. Hip dysplasia (HD) is a common musculoskeletal issue in CP patients. This study investigates the prevalence, risk factors, and impact of HD on CP patients using a large national database. : Data from the National Inpatient Sample (NIS) database (2016-2019) were used, identifying CP and HD diagnoses through ICD-10 codes. Baseline characteristics were tabulated. Univariate and multivariate logistic regression analyses examined predictors of HD development in CP patients, presenting data as odds ratios (ORs) with 95% confidence intervals (CIs). : Among 3,951,040 pediatric patients, 28,880 had CP (27,466 without HD, and 1414 with HD), and 3,922,160 did not have CP. CP significantly increased the likelihood of developing HD in univariate (OR = 35.03, 95% CI [33.01, 37.17], < 0.0001) and multivariate (OR = 26.61, 95% CI [24.94, 28.40], < 0.0001) analyses. Among patients with CP, race was significantly associated with HD, with ORs below 1 for all racial categories compared to Whites. Females had nearly twice the odds of HD compared to males (OR = 1.96, 95% CI [1.86, 2.05], < 0.0001). Age was significantly associated with HD, with each additional year increasing the odds (OR = 1.03, 95% CI [1.026, 1.034], < 0.0001). Individuals in the high 51st-75th income quartile had a 17% increase in the odds of HD (OR = 1.17, 95% CI [1.09, 1.25], < 0.0001) compared to the low 1st-25th income quartile. : This study reinforces the strong association between CP and HD, highlighting the need for further research and prospective studies to validate these findings.
脑性瘫痪（CP）在全球范围内显著影响生活质量。髋关节发育不良（HD）是 CP 患者常见的骨骼肌肉问题。本研究使用大型国家数据库调查了 HD 在 CP 患者中的患病率、危险因素和影响。
使用国家住院患者样本（NIS）数据库（2016-2019 年）的数据，通过 ICD-10 代码确定 CP 和 HD 诊断。列出了基线特征。单变量和多变量逻辑回归分析检查了 CP 患者发生 HD 的预测因素，数据以优势比（OR）和 95%置信区间（CI）表示。
在 3951040 名儿科患者中，28880 名患有 CP（27466 名无 HD，1414 名有 HD），3922160 名没有 CP。CP 在单变量（OR=35.03，95%CI[33.01，37.17]，<0.0001）和多变量（OR=26.61，95%CI[24.94，28.40]，<0.0001）分析中显著增加了发生 HD 的可能性。在 CP 患者中，种族与 HD 显著相关，与白人相比，所有种族类别的 OR 均低于 1。女性发生 HD 的几率几乎是男性的两倍（OR=1.96，95%CI[1.86，2.05]，<0.0001）。年龄与 HD 显著相关，每增加 1 岁，几率就会增加（OR=1.03，95%CI[1.026，1.034]，<0.0001）。与收入最低的 1-25%四分位数相比，收入处于较高的 51-75%四分位数的个体发生 HD 的几率增加了 17%（OR=1.17，95%CI[1.09，1.25]，<0.0001）。
本研究再次证实了 CP 和 HD 之间的强烈关联，强调需要进一步研究和前瞻性研究来验证这些发现。
