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儿科患者心房颤动的患病率、管理和结局:来自一家三级心脏病中心的见解。

Prevalence, Management, and Outcomes of Atrial Fibrillation in Paediatric Patients: Insights from a Tertiary Cardiology Centre.

机构信息

Pediatric Cardiology Department, Reference Center for Congenital Heart Diseases, Hospital de Santa Marta, Unidade Local de Saúde São José EPE, 1150-199 Lisbon, Portugal.

Centro Clínico Académico de Lisboa, Clínica Universitária de Cardiologia Pediátrica, 1169-045 Lisbon, Portugal.

出版信息

Medicina (Kaunas). 2024 Sep 15;60(9):1505. doi: 10.3390/medicina60091505.

DOI:10.3390/medicina60091505
PMID:39336546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11433662/
Abstract

Atrial fibrillation (AF) is increasingly recognised in paediatric patients, presenting unique challenges in management due to its association with various underlying heart conditions. This study aimed to evaluate the prevalence, management strategies, and outcomes of AF in this population. : A retrospective analysis was conducted at a tertiary paediatric cardiology centre, including patients aged ≤18 years diagnosed with AF between January 2015 and December 2023. The study focused on demographic details, clinical presentations, treatments, and outcomes. Descriptive statistics were employed to assess treatment efficacy, recurrence rates, and complications. : The study included 36 paediatric patients (median age: 15 years, IQR: 13-17; 58% male). Of these, 52.8% had acquired heart disease, 16.7% had congenital heart anomalies, and 16.7% presented with lone AF. The initial management strategies involved electrical cardioversion in 53.3% of patients and pharmacological conversion with amiodarone in 46.7%. Rhythm control therapy was administered to over 80% of the cohort, and 63.9% were placed on oral anticoagulation, predominantly for rheumatic and congenital heart diseases. The overall success rate of rhythm control was 96.2%, with an AF recurrence rate of 3.8%. Ischemic stroke was the most common complication, occurring in three patients, all with underlying rheumatic heart disease. : AF in paediatric patients is predominantly associated with rheumatic and congenital heart diseases, though a significant proportion of patients present with lone AF. Despite effective rhythm control in most cases, neurological complications, particularly ischemic strokes in patients with underlying heart disease, remain a critical concern. These findings underscore the need for more comprehensive studies to better understand the aetiology, risk factors, and optimal management strategies for paediatric AF.

摘要

心房颤动(AF)在儿科患者中越来越常见,由于其与各种潜在的心脏疾病有关,因此在管理方面带来了独特的挑战。本研究旨在评估该人群中 AF 的患病率、管理策略和结局。

本研究在一家三级儿科心脏病学中心进行了回顾性分析,纳入了 2015 年 1 月至 2023 年 12 月期间被诊断为 AF 的≤18 岁的患者。研究重点关注了人口统计学细节、临床表现、治疗和结局。采用描述性统计评估了治疗效果、复发率和并发症。

该研究共纳入 36 名儿科患者(中位数年龄:15 岁,IQR:13-17;58%为男性)。其中,52.8%患有获得性心脏病,16.7%患有先天性心脏畸形,16.7%为孤立性 AF。初始管理策略包括 53.3%的患者进行电复律,46.7%的患者使用胺碘酮进行药物复律。超过 80%的患者接受了节律控制治疗,63.9%的患者接受了口服抗凝治疗,主要用于风湿性和先天性心脏病。节律控制的总体成功率为 96.2%,AF 复发率为 3.8%。缺血性卒中是最常见的并发症,有 3 例患者发生,均患有潜在的风湿性心脏病。

儿科患者中的 AF 主要与风湿性和先天性心脏病有关,但仍有相当一部分患者表现为孤立性 AF。尽管大多数情况下节律控制效果良好,但神经并发症,特别是患有潜在心脏疾病的患者发生缺血性卒中,仍然是一个关键问题。这些发现突显了需要进行更全面的研究,以更好地了解儿科 AF 的病因、风险因素和最佳管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b8/11433662/e673ab4a27cb/medicina-60-01505-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b8/11433662/e673ab4a27cb/medicina-60-01505-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b8/11433662/e673ab4a27cb/medicina-60-01505-g001.jpg

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JACC Clin Electrophysiol. 2024 Mar;10(3):477-486. doi: 10.1016/j.jacep.2023.11.005. Epub 2023 Nov 22.
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Genetic Atrial Cardiomyopathies: Common Features, Specific Differences, and Broader Relevance to Understanding Atrial Cardiomyopathy.
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Circ Arrhythm Electrophysiol. 2023 Dec;16(12):675-698. doi: 10.1161/CIRCEP.123.003750. Epub 2023 Nov 29.
4
Orthostatic Stress and Baroreflex Sensitivity: A Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillation.直立位应激与压力反射敏感性:孤立性阵发性心房颤动自主神经功能障碍的一扇窗口
J Clin Med. 2023 Sep 8;12(18):5857. doi: 10.3390/jcm12185857.
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Case report: Mutation in gene as a cause of fibrotic atrial myopathy.病例报告:基因中的突变作为纤维化心房肌病的一个病因。
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