Department of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.
Medicina (Kaunas). 2024 Sep 15;60(9):1507. doi: 10.3390/medicina60091507.
Hepatic ischemia-reperfusion injury (IRI) is a major cause of postoperative hepatic dysfunction and liver failure involving cellular damage to previously ischemic tissues to which blood flow is restored. The reestablishment of blood flow is essential for salvaging ischemic tissues. The reperfusion itself, however, can paradoxically lead to further cellular damage, which involves a multi-factorial process resulting in extensive tissue damage, which can threaten the function and viability of the liver and other organ systems. The following review outlines multiple models for in-lab analysis of the various hepatic IRI mechanisms, including murine, porcine, cell lines, and machine perfusion models.
肝缺血再灌注损伤（IRI）是术后肝功能障碍和肝衰竭的主要原因，涉及到血流恢复到先前缺血组织的细胞损伤。血流的再建立对于挽救缺血组织是至关重要的。然而，再灌注本身可能会导致进一步的细胞损伤，这涉及一个多因素的过程，导致广泛的组织损伤，这可能会威胁到肝脏和其他器官系统的功能和存活。以下综述概述了多种用于实验室分析各种肝 IRI 机制的模型，包括鼠、猪、细胞系和机器灌注模型。
