Fabila-de la Cruz Oscar Daniel, Luna-Avila Eduardo Salif, Sotelo-González María Del Pilar, Litardo-Mosquera Andrés D, Orihuela Oscar, Ferreira-Hermosillo Aldo
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Servicio de Endocrinología, Hospital de Especialidades "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
J Clin Med. 2024 Sep 10;13(18):5351. doi: 10.3390/jcm13185351.
Diabetic cardiac muscle disease or diabetic cardiomyopathy (DbCM) comprises a set of myocardial lesions that are not associated with coronary atherosclerosis or high blood pressure. It is characterized by fibrosis and hypertrophy, which ultimately results in heart failure. Diastolic dysfunction (DD) has been shown to be the first manifestation of diabetic cardiomyopathy. Currently, there are few studies on the prevalence of diabetic cardiomyopathy in adult patients diagnosed with type 1 diabetes mellitus (T1D). The study included 75 adult participants who underwent an echocardiogram. Data on their comorbidities were collected from their medical records and biochemical parameters were analyzed in blood and urine samples. We found that the prevalence of DbCM in our T1D population was more than one-third (34%), which exceeded the prevalence reported in studies with adolescents and that reported in the population without diabetes. Also, we found that the probability of developing DD after 20 years of T1D diagnosis was 78%. Recommendations need to be issued in relation to diabetic cardiomyopathy to carry out secondary prevention in adult patients with T1D. More multicenter studies, which include a larger population, from different regions of the world need to be performed.
糖尿病性心肌病（DbCM）包括一组与冠状动脉粥样硬化或高血压无关的心肌病变。其特征为纤维化和肥大，最终导致心力衰竭。舒张功能障碍（DD）已被证明是糖尿病性心肌病的首发表现。目前，关于1型糖尿病（T1D）成年患者中糖尿病性心肌病患病率的研究较少。该研究纳入了75名接受超声心动图检查的成年参与者。从他们的病历中收集了合并症数据，并对血液和尿液样本中的生化参数进行了分析。我们发现，在我们的T1D人群中，糖尿病性心肌病的患病率超过三分之一（34%），超过了青少年研究和非糖尿病人群中的患病率报告。此外，我们发现，T1D诊断20年后发生DD的概率为78%。需要就糖尿病性心肌病发布建议，以便对成年T1D患者进行二级预防。需要开展更多来自世界不同地区、纳入更多人群的多中心研究。
